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Research compound — not a dietary supplement
Trenbolone (Finaplix) is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most Trenbolone (Finaplix) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2003–2024.
Based on 6 studies
Confidence
LowBy outcome
Trenbolone (Finaplix) has an evidence score of 3/10 — emerging evidence based on 6 indexed studies. A VETERINARY anabolic-androgenic steroid — trenbolone (acetate/enanthate, brands Finaplix/Revalor) — used only as a cattle growth promoter, NOT in humans, and a DEA Schedule III controlled substance. There are ZERO human efficacy trials and no human approval: the evidence base is animal toxicology, environmental endocrine-disruptor work on trenbolone as a feedlot/aquatic contaminant, and forensic residue/anti-doping detection — none of which shows a human benefit. A 19-nor (nandrolone-derived) steroid, trenbolone does NOT aromatize to estrogen but is highly androgenic and a strong progesterone-receptor agonist. In animals it causes potent HPTA/testosterone suppression with testicular damage and impaired fertility, and its metabolites (17β- and 17α-trenbolone) are documented aquatic endocrine disruptors that masculinize female fish at nanogram-per-litre levels. Illicit human users report severe HPTA shutdown, aggression, night sweats, insomnia, 'tren cough', severely worsened lipids, kidney strain, and progestin-driven prolactin effects/gynecomastia. It is NOT a dietary supplement, NOT a longevity drug, and illegal to possess or use without authorization. Informational, harm-reduction entry only — not a recommendation, and there is no legitimate human use to recommend. Representative study: PMID 38827655.
Yohimbine
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Ephedrine
Mostly mechanism / observationalLast reviewed June 2026 · evidence from 6 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Trenbolone (trenbolone acetate / enanthate; veterinary brands Finaplix, Revalor) — a synthetic 19-nor anabolic-androgenic steroid licensed only as a cattle growth promoter, with NO human approval and NO human efficacy trials; DEA Schedule III controlled substance
A VETERINARY anabolic-androgenic steroid — trenbolone (acetate/enanthate, brands Finaplix/Revalor) — used only as a cattle growth promoter, NOT in humans, and a DEA Schedule III controlled substance. There are ZERO human efficacy trials and no human approval: the evidence base is animal toxicology, environmental endocrine-disruptor work on trenbolone as a feedlot/aquatic contaminant, and forensic residue/anti-doping detection — none of which shows a human benefit. A 19-nor (nandrolone-derived) steroid, trenbolone does NOT aromatize to estrogen but is highly androgenic and a strong progesterone-receptor agonist. In animals it causes potent HPTA/testosterone suppression with testicular damage and impaired fertility, and its metabolites (17β- and 17α-trenbolone) are documented aquatic endocrine disruptors that masculinize female fish at nanogram-per-litre levels. Illicit human users report severe HPTA shutdown, aggression, night sweats, insomnia, 'tren cough', severely worsened lipids, kidney strain, and progestin-driven prolactin effects/gynecomastia. It is NOT a dietary supplement, NOT a longevity drug, and illegal to possess or use without authorization. Informational, harm-reduction entry only — not a recommendation, and there is no legitimate human use to recommend.
Trenbolone (Finaplix/Revalor, 'tren') is a VETERINARY anabolic-androgenic steroid used only as a cattle growth promoter, with NO human approval, NO human efficacy trials, and Schedule III controlled-substance status. Its entire evidence base is animal toxicology, environmental endocrine-disruptor science, and forensic residue/detection work — none of which demonstrates a human benefit, and most of which documents harm: testicular damage with suppressed testosterone/FSH/LH, lowered sperm quality and DNA damage/apoptosis in rats (Al-Otaibi 2024); potent androgenic endocrine disruption of fish at nanogram-per-litre levels, reducing fecundity and masculinizing females (Ankley 2003, Jensen 2006, Sone 2005); and validated detection of its residues/metabolites in livestock and human urine (Buiarelli 2003, Putz 2020). It does NOT aromatize but is highly androgenic and a strong progestin-receptor agonist, suppresses the HPTA, and carries the shared AAS risks. There is no human use to weigh in its favor, so the score sits low — reflecting an animal/environmental harm literature, not a supported benefit.
Trenbolone is a synthetic anabolic-androgenic steroid (AAS) — a 19-nor (estrane) compound derived from nandrolone — encountered as the short-acting acetate ester (veterinary brand Finaplix, and the Finaplix/Revalor cattle implants), the longer-acting enanthate, or the historical human hexahydrobenzylcarbonate ester (Parabolan, long discontinued).
Its only legitimate market is veterinary: trenbolone acetate is used as a growth promoter in beef cattle.
It has NEVER been approved for human therapeutic use (Parabolan, the one product ever marketed for humans, was withdrawn), there are NO human efficacy trials, and in the United States it is a Schedule III controlled substance under the Controlled Substances Act — possession or distribution without authorization is a federal crime.
The honest description of its evidence base is that it consists entirely of (1) animal toxicology — rodent studies of testicular harm, HPTA suppression and organ damage; (2) environmental endocrine-disruptor science — trenbolone and its metabolites 17β- and 17α-trenbolone are studied as feedlot-runoff and aquatic contaminants that masculinize and reduce the fertility of fish at nanogram-per-litre concentrations; and (3) forensic and anti-doping work on detecting trenbolone and its metabolites in animal tissue, bovine fluids and human urine.
There is no body of work showing it helps a human do anything. What the animal literature does establish is the harm profile.
In adult male rats, trenbolone ('Trenorol', 10 mg/kg intramuscularly weekly) significantly lowered testicular weight, total testosterone, follicle-stimulating hormone and luteinizing hormone, degraded sperm count, motility, viability and morphology, and raised testicular DNA damage and p53-driven apoptosis (Al-Otaibi 2024) — direct evidence of hypothalamic-pituitary-testicular-axis suppression, organ injury and impaired fertility.
The environmental literature is just as stark: 17β-trenbolone is a potent androgen and reproductive toxicant in fish, reducing fecundity in fathead minnows at concentrations as low as ~0.027 µg/L and inducing male-typical structures in females (Ankley 2003); its 17α metabolite is similarly active, reducing fecundity with an EC50 near 0.011 µg/L (Jensen 2006); and in mosquitofish it masculinized the anal fin into a gonopodium and drove ovotestis formation in female fry (Sone 2005) — the textbook profile of a powerful environmental endocrine disruptor.
The remaining 'real' literature is detection: validated LC-tandem-mass-spectrometry methods to flag illicit trenbolone use in bovine urine and serum (Buiarelli 2003) and hydrogen-isotope-ratio/high-resolution-MS methods that map trenbolone's excreted metabolites for human doping control (Putz 2020).
Pharmacologically, trenbolone differs from testosterone-class steroids in two important ways that shape its harm: it does NOT aromatize to estrogen (so classic estrogenic management does not apply), but it is a strong agonist at the progesterone receptor, and illicit users attribute prolactin-driven side effects — including a progestin-mediated gynecomastia, low libido and erectile problems — to that activity, on top of the shared AAS harms (profound HPTA/testosterone suppression, severely lowered HDL and a markedly adverse lipid shift, renal strain, virilization in women, and the cardiovascular risk of supraphysiologic androgen use).
Illicit-user reports also describe aggression and mood disturbance, insomnia, drenching night sweats, and an acute coughing fit on injection ('tren cough').
The score reflects the reality squarely: a veterinary growth-promoter steroid with ZERO human efficacy trials and no human approval, an evidence base that is animal toxicology, environmental endocrine disruption and forensic residue detection rather than benefit, documented testicular and organ harm and HPTA suppression in animals, potent environmental androgenic/endocrine-disruptor activity, strong progestin-receptor effects, and Schedule III legal status.
It is not a dietary supplement, not a longevity drug, and there is no medical or performance use this library endorses.
Trenbolone is a 19-nor steroid that binds the androgen receptor with high affinity — higher than testosterone in fish binding assays — driving potent anabolic (protein-building) and androgenic signalling, the basis of its use as a cattle growth promoter and its illicit muscle-building use. Unlike testosterone it does NOT aromatize to estrogen, so estrogenic management does not apply; its harms are androgenic and progestogenic rather than estrogenic.
As a 19-nor (nandrolone-derived) compound, trenbolone is a strong agonist at the progesterone receptor. Illicit human users attribute progestin/prolactin-driven side effects to this activity — gynecomastia despite no aromatization, lowered libido and erectile dysfunction — a harm pathway distinct from the estrogenic one seen with aromatizing steroids.
Exogenous androgen suppresses the hypothalamic-pituitary-testicular axis — in rats trenbolone lowered LH, FSH and testosterone with testicular injury and impaired sperm parameters. The same potent androgenic activity makes trenbolone and its metabolites (17β-/17α-trenbolone) documented aquatic endocrine disruptors that masculinize female fish and reduce fecundity at nanogram-per-litre levels, the dominant signal in trenbolone's evidence base.
How Trenbolone (Finaplix) works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Tap node to isolate • Pinch to zoom • Tap edge for research
There is no legitimate human dose. Trenbolone is a VETERINARY anabolic-androgenic steroid (a cattle growth promoter) and a DEA Schedule III controlled substance with no human approval and no human efficacy trials; this library does NOT provide a human dosing protocol of any kind. For context only, the rat toxicology study dosed trenbolone at 10 mg/kg intramuscularly once weekly — a research dose used to characterize harm, not a human recommendation. Illicit bodybuilding 'tren' dosing (commonly tens to hundreds of mg per week of the acetate or enanthate ester intramuscularly) is unstudied in humans, unmonitored, and illegal without authorization.
Can be taken without food
| Form | Type |
|---|---|
| 💊Veterinary intramuscular trenbolone acetate (Finaplix/Revalor) — for veterinary use in cattle only; no human form is endorsed | Recommended |
There is no legitimate over-the-counter, supplement or human-prescription form (Parabolan, the one human ester ever marketed, was withdrawn). It is a Schedule III controlled substance; non-veterinary material ('tren') is illegal to possess without authorization and frequently counterfeit.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: No human timing is endorsed. Trenbolone is a veterinary controlled-substance steroid with no human approval, animal testicular/organ-toxicity and HPTA-suppression signals, potent environmental endocrine-disruptor activity, and strong progestin-receptor effects. This library does not schedule its use.
Dose-response data unavailable. The current published research for Trenbolone (Finaplix) does not provide sufficient dose-specific outcome data to generate reliable dose-response curves.
Refer to the Dosage & Timing section above for recommended dose ranges based on available evidence.
There is no human approval, no human efficacy trials, and no demonstrated human benefit for trenbolone of any kind. It is a veterinary cattle growth promoter; everything known comes from animal toxicology, environmental endocrine-disruptor science, and forensic residue/anti-doping detection. Any 'benefit' attributed to it in bodybuilding is extrapolated from animal androgen effects, not from human evidence.
In adult male rats, trenbolone significantly lowered testicular weight, total testosterone, FSH and LH, degraded sperm count, motility, viability and morphology, and raised testicular DNA damage and p53-driven apoptosis — direct evidence of HPTA suppression, organ injury and impaired fertility.
Trenbolone's metabolites 17β- and 17α-trenbolone are potent androgens and reproductive toxicants in fish — reducing fecundity at nanogram-per-litre concentrations, inducing male-typical structures in females, and driving ovotestis formation in fry. Trenbolone is a feedlot-runoff and aquatic contaminant studied as a textbook endocrine disruptor.
Trenbolone does NOT aromatize to estrogen but is a strong progesterone-receptor agonist; illicit human users attribute progestin/prolactin-driven gynecomastia, lowered libido and erectile dysfunction to this activity — a harm pathway distinct from the estrogenic effects of aromatizing steroids, and one that estrogen-blocking drugs do not address.
Illicit users and the AAS literature describe a markedly adverse lipid shift (severely lowered HDL) and renal strain with trenbolone, on top of the cardiovascular risk of supraphysiologic androgen use. No protective human data offsets these signals; reports also include aggression, insomnia and drenching night sweats.
Trenbolone is a high-affinity androgen-receptor agonist and is licensed as a cattle growth promoter — the basis of its illicit bodybuilding use. But the only anabolic evidence is in animals, it comes bundled with potent organ and reproductive toxicity, and there is no human efficacy trial demonstrating safe or effective muscle gain.
Avoid — a veterinary controlled-substance steroid with no human evidence of benefit, a documented animal/environmental harm profile (testis, fertility, endocrine disruption), strong progestin-receptor effects, and illegal to use without authorization. Not a supplement.
Avoid — trenbolone strongly suppressed the gonadal axis and damaged the testes in animal studies; non-medical use risks impaired fertility with no monitoring.
Avoid — potently androgenic and progestogenic; virilizing effects can be permanent.
Avoid entirely — androgenic and progestogenic with fetal-virilization risk.
Anabolic steroids as a class can potentiate warfarin and raise bleeding risk; trenbolone's interactions are uncharacterised in humans, so any concurrent use would be unmonitored and unpredictable.
Stacking androgenic agents compounds HPTA suppression, the adverse lipid shift and progestogenic effects; the combined harm is additive and entirely uncharacterised in non-medical use.
Tip: In rats, trenbolone lowered LH, FSH and testosterone, reduced testicular weight, and degraded sperm count/motility/viability/morphology with testicular DNA damage and apoptosis. As a potent exogenous androgen it strongly suppresses the human HPTA too; recovery after non-medical use is variable and unmonitored.
Tip: Trenbolone does not aromatize but is a strong progesterone-receptor agonist; illicit users report progestin/prolactin-driven gynecomastia, lowered libido and erectile dysfunction. Estrogen-blocking drugs do not address this, and there is no monitored way to manage it in non-medical use.
Tip: Trenbolone is associated with a severely lowered HDL and a markedly adverse lipid shift, with reports of renal strain, on top of the cardiomyopathy/atherosclerosis risk of supraphysiologic androgen use. Report chest pain, breathlessness, palpitations or dark/reduced urine; unmonitored in non-medical use.
Tip: Illicit users commonly report aggression and irritability, anxiety, insomnia and drenching night sweats with trenbolone. These behavioral/sleep effects are unpredictable and unmonitored in non-medical use.
The commonly studied dose of Trenbolone (Finaplix) is There is no legitimate human dose. Trenbolone is a VETERINARY anabolic-androgenic steroid (a cattle growth promoter) and a DEA Schedule III controlled substance with no human approval and no human efficacy trials; this library does NOT provide a human dosing protocol of any kind. For context only, the rat toxicology study dosed trenbolone at 10 mg/kg intramuscularly once weekly — a research dose used to characterize harm, not a human recommendation. Illicit bodybuilding 'tren' dosing (commonly tens to hundreds of mg per week of the acetate or enanthate ester intramuscularly) is unstudied in humans, unmonitored, and illegal without authorization.. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
Timing is flexible for Trenbolone (Finaplix) — consistent daily use matters more than the time of day. Trenbolone acetate/enanthate is an oil-based intramuscular veterinary ester.
Trenbolone (Finaplix) should be used with caution — talk to a healthcare provider before taking it. The most commonly reported side effects are HPTA suppression & impaired fertility (animal), progestin / prolactin effects (gynecomastia, low libido), adverse lipids / cardiovascular & renal strain. Use caution if any of these apply to you: Any human use — a VETERINARY DEA Schedule III controlled substance with no human approval and no human efficacy trials; possession/use without authorization is illegal, and it is not a dietary supplement; Anyone seeking it for body composition, performance or anti-aging — there is no human evidence of benefit and a documented animal/environmental harm profile; Pregnancy and breastfeeding — potently androgenic and progestogenic, with fetal-virilization risk.
A sympathomimetic stimulant — the 'E' in the ECA (ephedrine/caffeine/aspirin) fat-loss stack. Ephedrine plus caffeine genuinely produces MODEST fat loss in 6-month RCTs (~0.9 kg/month more than placebo, ~3 kg over a controlled diet trial). But that is the whole upside: ephedra alkaloids were BANNED from US dietary supplements in 2004 after the FDA tied them to cardiovascular and psychiatric harms and deaths (the JAMA meta-analysis found a 2.2–3.6× increase in psychiatric/autonomic/GI symptoms and palpitations). Pharmaceutical ephedrine survives only as a restricted behind-the-counter decongestant/vasopressor. NOT a dietary supplement, NOT a longevity drug — a gated harm-reduction entry.
Illicit users co-administer dopamine agonists to blunt trenbolone's progestin/prolactin-driven effects (gynecomastia, low libido); this is an unmonitored attempt to manage a harm of an unapproved drug, not a sanctioned regimen, and these drugs carry their own risks.
Trenbolone use is associated with renal strain and a markedly adverse lipid shift; combining it with other nephrotoxic or hepatotoxic agents or heavy alcohol adds avoidable organ risk in an already unmonitored setting.
Tip: As a potent androgen, trenbolone can cause deepened voice, hirsutism and other virilizing changes that may be irreversible in women. Avoid entirely.
Tip: Illicit injectors commonly report an acute, sometimes severe coughing fit immediately after injecting trenbolone. It is unpredictable, occurs in an illegal unmonitored setting, and is one of several reasons there is no safe way to use this compound.