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Tt5.5
Tribulus Research
Likely helps
44 peer-reviewed studies
What the evidence says
Likely helps
Tribulus appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2000–2026 with a typical study size of 67 participants.
Based on 44 studies · 3 meta-analyses · 28 RCTs · 4,732 total participants
Confidence
High confidence
What the studies found
4helped· 40 more without graded effect data
By outcome
Men's vitalitySteroidal saponins may support hormonal balance · 4-8 weeks · Modest libido improvements · 4-8 weeks
Mostly mechanism / observational38 studies
Women's healthMay help manage menopausal symptoms like hot flashes and mood changes · 4-8 weeks · Supports healthy estrogen metabolism and hormonal equilibrium · 4-8 weeks
Mostly mechanism / observational9 studies
Fertility & reproductiveMay support reproductive health and fertility markers · 4-12 weeks
Mostly mechanism / observational4 studies
Safety profile
Mostly mechanism / observational4 studies
Lean body mass & muscle growthEnhanced libido and sexual desire · 2-4 weeks
Mostly mechanism / observational3 studies
Therapeutic & clinical
Mostly mechanism / observational3 studies
Muscle strength & powerEnhanced libido and sexual desire · 2-4 weeks
Too few graded studies2 studies
Endurance & exercise performance
Too few graded studies2 studies
Heart & blood pressure
Too few graded studies2 studies
Cholesterol & lipids
Too few graded studies2 studies
By the numbers
Pulled from 23 studies with measurable effects
Likely real effects
83%
across studies
People studied
4,732
typical study: 67 people
Strongest designs
31
3 pooled, 28 randomised
Showed benefit
100%
4/4 studies
How long studies ran
1–4 weeks
1
1–3 months
4
Populations Studied
Men with erectile dysfunction2
Women with female sexual dysfunction1
Healthy men1
Males with testosterone or erectile dysfunction concerns1
Active research area
19 studies in the last 5 years · Latest meta-analysis: 2026
200020132026
1Systematic Reviewn=279 · medium study2020
In plain English: After 1 to 3 months of treatment, premenopausal and postmenopausal women randomized to T. terrestris had a significant increase in sexual function scores.
Martimbianco ALC et al. · Revista brasileira de ginecologia e obstetricia (2020)
After the selection process, conducted by two reviewers, 5 RCTs (n = 279 participants) were included.
Three months of treatment with T. terrestris showed a significant increase in the serum testosterone levels of premenopausal women.
The certainty of the evidence was very low, which means that we have very little confidence in the effect estimates, and future studies are likely to change these estimates.
2Overall female sexual functionMeta-Analysisn=536 · large study2021
In plain English: Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.
Sha'ari N et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2021)
Huge benefit
← WorseNo effectBetter →
Likely real
Tribulus terrestris showed a significant positive effect in improving overall female sexual function (SMD = 1.12, 95% CI = 0.46 - 1.79, p = 0.001) compared to placebo.
Tribulus terrestris also improved individual sexual arousal (SMD = 1.03, 95% CI = 0.22 - 1.84, p = 0.013) and sexual desire (SMD = 1.08, 95% CI = 0.52 - 1.63) domains.
Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.
Suharyani S et al. · International journal of impotence research (2026)
Noticeable benefit
← WorseNo effectBetter →
Likely real
The outcomes of continuous variables were aggregated into the mean difference (MD) with corresponding 95% confidence intervals (95% CI) utilizing random-effects models.
Additionally, on both the IIEF-5 [MD 3.23 (95%CI 1.89, 4.58), p < 0.00001] and IIEF-15 [MD 14.44 (95%CI 5.75, 23.14), p = 0.001], Tribulus terrestris outperformed placebo.
However, the two groups were not significantly different in terms of total testosterone levels.
In plain English: DSs marketed in Italy are usually blends of many substances that are frequently employed at a negligible dose or without any evidence.
Petre GC et al. · Nutrients (2023)
Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy.
A systematic review of the literature was performed to evaluate the effect of DS and to detect the active ingredients able to improve erectile function-called effective ingredients (EIs)-and their minimal effective daily dose (mED).
A metanalysis identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris and L-arginine, that are able to improve male sexual function.
7Testosterone and erectile dysfunction parametersSystematic Review2021
In plain English: Many male supplements claim to improve testosterone or ED parameters; however, there is limited evidence, which should be considered when counseling patients.
Kuchakulla M et al. · International journal of impotence research (2021)
No whole supplement products have published RCT evidence. 19% of ingredients received an A grade for strong positive evidence with net positive evidence in two or more RCTs.
In total, 68% received C or D grades for contradicting, negative, or lacking evidence.
Overall, 69% of ingredients in testosterone supplements and 52% of ingredients in ED supplements have published RCT evidence.
9UTI management with medicinal plantsSystematic Review2019
In plain English: Although herbal medicines have more potential over conventional medicine but more discoveries are required to explore the phytoconstituents and their mechanism of action responsible for the management and cure of UTI.
Shaheen G et al. · Clinical and experimental pharmacology & physiology (2019)
Herbal medicines are effective to combat bacterial resistance with high efficacy, and easy availability with minimal or no side effects.
For these reasons it has attained the attention of researchers wanting to explore the herbal treatment of UTI.
Vaccinium macrocarpon, Tribulus terrestris, Trachyspermum copticum, Cinnamomum verum and Hybanthusenn easpermus are some common medicinal plants reported to have therapeutic potential for the management and cure of the UTI.
In plain English: The nitric oxide release effect of TT may offer a plausible explanation for the observed physiological responses to TT supplementation, independent of the testosterone level.
Qureshi A et al. · Journal of dietary supplements (2014)
A limited number of animal studies displayed a significant increase in serum testosterone levels after TT administration, but this effect was only noted in humans when TT was part of a combined supplement administration.
Literature available for the effectiveness of TT on enhancing testosterone concentrations is limited.
Evidence to date suggests that TT is ineffective for increasing testosterone levels in humans, thus marketing claims are unsubstantiated.
In plain English: The results of the present systematic review showed that the consumption of T terrestris L., in general, resulted in the improvement of sperm parameters.
Sanagoo S et al. · Complementary therapies in medicine (2019)
The results of the present systematic review showed that the consumption of T terrestris L., in general, resulted in the improvement of sperm parameters.
This result was obtained from 6 out of the 7 articles.
13Bacterial vaginitis treatmentRCTn=127 · medium study2018
In plain English: A clinical study with a longer follow-up time is suggested for assessing the recurrence of BV after treatment with Forzejeh metronidazole.
Baery N et al. · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2018)
Likely real
The amount and odour of discharge, Amsel criteria, pelvic pain and cervical inflammation significantly decreased in Forzejeh and metronidazole groups (p = <.001).
There was no statistically significant difference between the metronidazole and Fozejeh groups with respect to any of the clinical symptoms or the laboratory assessments.
In plain English: The test drug Khār-i-khasak (T. terrestris Linn.) was found to be effective and safe in lowering blood pressure compared to placebo in prehypertensive individuals.
Siddiqui MA et al. · Journal of complementary & integrative medicine (2021)
The test drug Khār-i-khasak (T. terrestris Linn.) was found to be effective and safe in lowering blood pressure compared to placebo in prehypertensive individuals.