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Tph3.5
Triphala Research
Mostly mechanism / observational
22 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Triphala studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2026 with a typical study size of 104 participants.
Based on 22 studies · 1 meta-analysis · 15 RCTs · 14,100 total participants
Confidence
High confidence
By outcome
Glucose & metabolicAntioxidant and hypoglycemic effects reported in preclinical and small studies; human metabolic evidence is limited · Unknown
Too few graded studies1 study
Active research area
10 studies in the last 5 years · Latest meta-analysis: 2020
In plain English: Triphala supplementation did not provide any additional statistically significant benefit but was safe and well tolerated.
Padkao T, Intakhiao S, Prakobkaew N, Buddhisa S, Teethaisong Y, Boonla O, Prasertsri P. · International journal of molecular sciences (2025)
Following the intervention, significant reductions in IFN-γ, TNF-α, MDA, protein carbonyls, and rating of perceived exertion were observed in both the HIIT and combined groups ( p < 0.05), with no significant differences between the two.
SOD activity significantly increased in all groups, including the control group ( p < 0.05), with no between-group differences.
Triphala supplementation did not provide any additional statistically significant benefit but was safe and well tolerated.
17Systematic Reviewn=13,906 · very large study2024
Woolhiser E, Keime N, Patel A, Weber I, Adelman M, Dellavalle RP. · JMIR dermatology (2024)
Seborrheic dermatitis was correlated with significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations.
Most studies find associations between regular alcohol use and seborrheic dermatitis, but the association between BMI and obesity on seborrheic dermatitis severity and prevalence is mixed.
Conclusions This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for seborrheic dermatitis.
In plain English: Hence, this review thoroughly examines the pharmacological advantages of Triphala with special emphasis on molecular mechanisms altering the gut-microbiota prior to its potential utilization in clinical environments.
It is also effective against parasitic infections, and other infectious disorders.
Although, the mechanisms are not well explored but these activities are also ascribed to alter the gut microbiota composition.
Therefore, it is imperative to undertake rigorous systematic study for TLP in order to identify and assess the chemical ingredients which bring about the change either in gut microbiome composition or increase the number of beneficial gut-microbiota.
In plain English: Conclusions The study is expected to demonstrate the efficacy of an Ayurvedic management protocol on the rate of recurrence, healing, and safety in Parikarthika (fissure in ano).
P P I, Kachare K, K M PS, P B, S L, Sharma BS, Maheswar T, Tripathi A, Srikanth N, Acharya R. · JMIR research protocols (2026)
The recurrence rate of fissure in ano by nonsurgical procedures is 60%, and with the Ayurveda protocol, the expected recurrence rate is 30%.
Results This project was funded in June 2024, and the study duration is 36 months.
The first participant was enrolled in April 2025; 9 participants were enrolled as of May 2025.
In plain English: Triphala is a cornerstone of gastrointestinal and rejuvenative treatment, and its polyphenols modulate the human gut microbiome, promoting beneficial Bifidobacteria and Lactobacillus.
Peterson CT, Denniston K, Chopra D · J Altern Complement Med (2017)
Reviews laxative action plus appetite stimulation, reduced hyperacidity, antioxidant, anti-inflammatory, and immunomodulating effects
Polyphenols promote beneficial gut bacteria and are metabolized into anti-inflammatory compounds
Notes hypoglycemic, antimutagenic, and chemoprotective effects from preclinical work