40 peer-reviewed studies · Evidence score: 8.5/10
Alotaibi G et al. • European journal of pharmacology (2025)
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation.
Luo W et al. • Frontiers in immunology (2025)
Collectively, microbiota-derived metabolites represent promising targets for precision diagnosis and treatment in GI cancer immunotherapy.
Izenberg A • Continuum (Minneapolis, Minn.) (2023)
The evolving understanding of the genetic and pathophysiologic underpinnings of disease offers promise for more effective and clinically meaningful treatments in the future.
Freitas IN et al. • Frontiers in endocrinology (2023)
Therefore, TUDCA has emerged as a potential therapeutic strategy for obesity and comorbidities.
Zangerolamo L et al. • Life sciences (2021)
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
McCarty MF • International journal of molecular sciences (2021)
Research Strategy: Key word searching of PubMed was employed to locate the research papers whose findings are cited in this essay.
Li J et al. • Current neuropharmacology (2024)
This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment.
Huang F et al. • Brain, behavior, and immunity (2022)
Overall, this review confirms the therapeutic potential of UDCA, GUDCA and TUDCA in neurological, neurodegenerative and neuropsychiatric disorders, proposing bile acids as potential alternative the...
Sun Y et al. • Amyotrophic lateral sclerosis & frontotemporal degeneration (2022)
Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.
Yang Z et al. • European journal of medical research (2022)
This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
Grant SM et al. • International journal of molecular sciences (2020)
This review explores the findings of recent studies highlighting bile acid-mediated therapies and bile acid-mediated signaling and the roles they play in neurodegenerative and neurological diseases.
Marques N et al. • Journal of the American Heart Association (2020)
Novel therapeutic targets including transthyretin gene silencers are currently under investigation.
Xia SW et al. • Pharmacological research (2020)
Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded protein response (UPR).
Daruich A et al. • Molecular vision (2019)
As secondary bile acids are generated by the microbiota metabolism, bile acids might be a link between neurodegenerative retinal diseases and microbiota.
Głowacka P et al. • Polish journal of microbiology (2018)
Currently, also other methods are used to disrupt Brucella intracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
Pardue MT et al. • Progress in retinal and eye research (2018)
We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.
Cnop M et al. • Molecular metabolism (2017)
Pancreatic β cells are sensitive to excessive endoplasmic reticulum stress and dysregulated eIF2α phosphorylation, as indicated by transcriptome data, monogenic forms of diabetes and pharmacological studies.
Xavier JM et al. • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2016)
In this review, we discuss recent evidence extending the importance of mitochondrial function and energy metabolism to the context of neuronal development and adult neurogenesis.© The Author(s) 2015.
Vega H et al. • IUBMB life (2016)
We propose the term "proteostasis promoters" as a more accurate descriptor for a class of compounds that demonstrate ability to promote proteostasis by modulating the UPR and/or the function of chaperones. © 2016 IUBMB Life, 68(12):943-954, 2016.
Adams D et al. • Current opinion in neurology (2012)
There is better recognition of amyloid neuropathies, and hope for enrolling patients with FAP in future clinical trials testing new antiamyloid drugs.