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Research compound — not a dietary supplement
Turinabol (4-Chlorodehydromethyltestosterone) is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most Turinabol (4-Chlorodehydromethyltestosterone) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 1997–2026 with a typical study size of 5 participants.
Based on 6 studies · 5 total participants
Confidence
LowBy outcome
Turinabol (4-Chlorodehydromethyltestosterone) has an evidence score of 3/10 — emerging evidence based on 6 indexed studies. An oral 17α-alkylated anabolic-androgenic steroid (AAS) — 'Oral Turinabol', developed by Jenapharm in the 1960s — and a DEA Schedule III CONTROLLED SUBSTANCE. It is most notable as the central drug of the state-sponsored doping program of the former German Democratic Republic (East Germany), which administered androgens to several thousand athletes a year, including minors and women, often without their knowledge or consent. There are NO legitimate modern efficacy trials: the substantial human record is the documented harm of that coercive program (irreversible virilization in women and girls, hepatic injury, cardiovascular events, and psychological damage) plus anti-doping detection/pharmacology work. It is 17α-alkylated and hepatotoxic, suppresses the hypothalamic-pituitary-testicular axis, and virilizes. It is NOT a dietary supplement, NOT a longevity drug, and non-medical use is illegal without a prescription. Informational, harm-reduction entry only — not a recommendation. Representative study: PMID 9216474.
Yohimbine
Mostly mechanism / observationalThe purified alkaloid (not crude yohimbe bark) — an alpha-2 adrenoceptor antagonist with modest evidence for erectile dysfunction and fasted fat loss, but real anxiety and cardiovascular risks and notoriously mislabeled supplement potency.
Ephedrine
Mostly mechanism / observationalLast reviewed June 2026 · evidence from 6 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Turinabol (Oral Turinabol, 4-chlorodehydromethyltestosterone / dehydrochloromethyltestosterone) — oral 17α-alkylated anabolic-androgenic steroid; DEA Schedule III controlled substance
An oral 17α-alkylated anabolic-androgenic steroid (AAS) — 'Oral Turinabol', developed by Jenapharm in the 1960s — and a DEA Schedule III CONTROLLED SUBSTANCE. It is most notable as the central drug of the state-sponsored doping program of the former German Democratic Republic (East Germany), which administered androgens to several thousand athletes a year, including minors and women, often without their knowledge or consent. There are NO legitimate modern efficacy trials: the substantial human record is the documented harm of that coercive program (irreversible virilization in women and girls, hepatic injury, cardiovascular events, and psychological damage) plus anti-doping detection/pharmacology work. It is 17α-alkylated and hepatotoxic, suppresses the hypothalamic-pituitary-testicular axis, and virilizes. It is NOT a dietary supplement, NOT a longevity drug, and non-medical use is illegal without a prescription. Informational, harm-reduction entry only — not a recommendation.
Turinabol ('Oral Turinabol', 4-chlorodehydromethyltestosterone) is a DEA Schedule III controlled-substance, oral 17α-alkylated anabolic-androgenic steroid with NO legitimate modern efficacy trials. Its only substantial human record is the documented harm of the East German (GDR) state doping program, which dosed several thousand athletes a year — including minors and women — often without consent, causing irreversible virilization, hepatic and cardiovascular injury, and psychiatric damage. Case reports document fatal cardiovascular events and a testicular leiomyosarcoma after high-dose use; pharmacology and anti-doping work confirm it is a non-aromatizing AAS that is hepatotoxic, suppresses the HPTA, and virilizes. It is not a dietary supplement and not a longevity drug. The low score reflects a controlled substance with documented serious harm and no efficacy evidence to offset it.
Turinabol (4-chlorodehydromethyltestosterone, also called dehydrochloromethyltestosterone or DHCMT, marketed as 'Oral Turinabol') is an oral 17α-alkylated anabolic-androgenic steroid (AAS) — a chlorinated, non-aromatizing analogue of metandienone (Dianabol).
It was synthesized and marketed by the East German pharmaceutical firm Jenapharm in the 1960s. The 17-alpha-alkyl group lets it survive first-pass liver metabolism so it can be taken by mouth; the 4-chloro substitution blocks aromatization to estrogen.
In the United States it is a Schedule III controlled substance under the Controlled Substances Act; possession or distribution without a valid prescription is a federal crime, and it has no current accepted medical use as a supplement or longevity agent.
What makes turinabol historically singular is not a clinical indication but a crime against athletes. From 1966 onward it was the central drug of a conspiratorial, state-directed doping program run by the government of the German Democratic Republic (East Germany).
As documented from classified Stasi files after 1990 by Franke and Berendonk (Clinical Chemistry, 1997), hundreds of physicians and scientists administered androgens — Oral Turinabol foremost among them — to several thousand athletes every year, including minors of both sexes, frequently without their knowledge, information, or consent, and despite known health risks.
Special emphasis was placed on dosing women and adolescent girls because the performance gains were largest there; the cost was severe and often irreversible virilization.
A 2026 review (Spitzer and Bley) estimates roughly 15,000 underage athletes were affected and catalogues the lasting biopsychosocial damage — disrupted hormonal regulation, organ damage, and psychiatric harm — still evident in survivors decades later.
The honest evidentiary picture for this collection is therefore the opposite of an efficacy file.
There are NO modern, legitimate randomized efficacy trials of turinabol for body composition, performance, or any approved indication; the only substantial human 'data' is the harm record of a coercive state program, supplemented by case reports of catastrophic outcomes (fatal myocardial infarction, stroke, atherosclerosis and organomegaly after long-term abuse in Madea 1998; an intratesticular leiomyosarcoma in a young man after five years of high-dose Oral Turinabol in Froehner 1999) and by anti-doping science — controlled-administration metabolite-excretion studies (Loke 2021) and detection methods that exist precisely because the drug is banned in sport at all times.
Mechanistically it is an androgen-receptor agonist driving muscle and strength, and as a 17α-alkylated AAS it carries the class harms: hepatotoxicity (transaminitis, cholestasis, peliosis hepatis and liver-tumour risk), suppression of the hypothalamic-pituitary-testicular axis, an adverse lipid shift, and virilization (Kicman 2008).
The score is low by design: a controlled-substance steroid with documented, sometimes irreversible human harm — including in coerced minors — and no legitimate efficacy evidence to weigh against it. This entry exists for documentation and harm reduction, not as a recommendation.
Turinabol is a chlorinated, 17α-alkylated testosterone derivative that binds and activates the androgen receptor in skeletal muscle, driving the anabolic, strength-increasing signalling sought in doping. The 17α-alkyl group makes it orally active by surviving first-pass metabolism; the 4-chloro substitution blocks aromatization to estrogen, so its androgenic and virilizing effects are not buffered by estrogenic activity.
Androgen-receptor activation increases net protein anabolism and lean mass and raises strength — the performance effect that made it the centerpiece of the GDR doping program, where the largest measured gains were in women and adolescent girls.
The 17α-alkyl group that makes turinabol orally active also makes it hepatotoxic (transaminitis, cholestasis, and for AAS broadly peliosis and liver tumours). Its unopposed androgenic activity virilizes — irreversibly in women and girls — suppresses the hypothalamic-pituitary-testicular axis, shifts the lipid profile adversely, and, with long-term abuse, is linked to cardiovascular catastrophe and psychiatric harm; these are the documented outcomes in GDR doping survivors.
How Turinabol (4-Chlorodehydromethyltestosterone) works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Tap node to isolate • Pinch to zoom • Tap edge for research
There is no legitimate medical or non-medical dose. Turinabol is a DEA Schedule III controlled substance with no current accepted supplement or longevity use; this library does NOT provide a dosing protocol. For historical and harm-reduction context only: a controlled anti-doping administration study used a single 5 mg oral dose, and the GDR program used escalating illicit doses in athletes. None of this is an endorsement of self-administration — possession or use without a prescription is illegal.
Can be taken without food
| Form | Type |
|---|---|
| 💊None — no legitimate over-the-counter, supplement, or prescription form is endorsed | Recommended |
Turinabol is a Schedule III controlled substance; non-prescription material is illegal to possess, frequently counterfeit, and used without medical monitoring.
Minimum: 1 weeks
Optimal: 6 weeks
Cycling: Not required
Note: No timing is endorsed. It is a controlled-substance anabolic steroid with documented serious harm and no legitimate medical or supplement use; this library does not schedule its use.
Dose-response data unavailable. The current published research for Turinabol (4-Chlorodehydromethyltestosterone) does not provide sufficient dose-specific outcome data to generate reliable dose-response curves.
Refer to the Dosage & Timing section above for recommended dose ranges based on available evidence.
As an androgen-receptor agonist, turinabol increases lean mass and strength — the performance enhancement for which the GDR program administered it. This is the reason it was abused, not a sanctioned benefit; there are no modern efficacy trials quantifying it.
The documented signature harm of the GDR program: deepened voice, hirsutism, clitoral enlargement and menstrual disruption in women and adolescent girls, frequently permanent. The largest performance gains — and the worst virilization — occurred in female and underage athletes dosed without consent.
17α-alkylated and hepatotoxic — liver-enzyme elevation, cholestasis, and for the AAS class peliosis hepatis and liver tumours. A case of intratesticular leiomyosarcoma was reported after five years of high-dose Oral Turinabol.
Long-term AAS abuse, including Oral Turinabol, is linked in forensic case material to fatal myocardial infarction, stroke, severe atherosclerosis and organomegaly, alongside an adverse HDL/LDL shift.
Suppresses the hypothalamic-pituitary-testicular axis (LH, FSH, testosterone), and — documented in GDR doping survivors — contributes to lasting psychological and biopsychosocial damage, the more so because many were dosed as minors without consent.
Avoid — a controlled-substance anabolic steroid with documented serious harm and no efficacy evidence; illegal to use without a prescription and not a supplement.
Avoid entirely — virilizing effects (voice deepening, hirsutism, clitoral enlargement) can be permanent; the GDR program's irreversible harms concentrated in women and underage girls.
Avoid entirely — androgenic; causes fetal virilization.
Avoid — hepatotoxic and potentiates anticoagulants; serious interaction and injury risk with no medical monitoring in non-prescription use.
17α-alkylated anabolic steroids potentiate warfarin and raise INR and bleeding risk; this is an established AAS-class interaction requiring clinician-managed dose adjustment.
Turinabol is itself hepatotoxic; combining it with other hepatotoxic agents or alcohol compounds the risk of transaminitis and cholestatic injury.
Tip: Often irreversible in women and girls — the documented signature harm of the GDR program. There is no safe self-administration framework; the only reliable mitigation is not to use it.
Tip: 17α-alkylated and hepatotoxic; AAS as a class are linked to peliosis hepatis, hepatic adenoma and hepatocellular carcinoma, and a testicular leiomyosarcoma was reported after high-dose use. Seek care for jaundice, dark urine, or abdominal pain.
Tip: Long-term AAS abuse including Oral Turinabol is linked in forensic case material to fatal myocardial infarction, stroke and severe atherosclerosis, with lowered HDL and raised LDL. No safe non-medical monitoring exists.
Tip: Suppresses LH, FSH and endogenous testosterone; documented lasting psychological and biopsychosocial damage in GDR doping survivors, especially those dosed as minors.
The commonly studied dose of Turinabol (4-Chlorodehydromethyltestosterone) is There is no legitimate medical or non-medical dose. Turinabol is a DEA Schedule III controlled substance with no current accepted supplement or longevity use; this library does NOT provide a dosing protocol. For historical and harm-reduction context only: a controlled anti-doping administration study used a single 5 mg oral dose, and the GDR program used escalating illicit doses in athletes. None of this is an endorsement of self-administration — possession or use without a prescription is illegal.. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
Timing is flexible for Turinabol (4-Chlorodehydromethyltestosterone) — consistent daily use matters more than the time of day. There is no endorsed administration protocol.
Turinabol (4-Chlorodehydromethyltestosterone) should be used with caution — talk to a healthcare provider before taking it. The most commonly reported side effects are virilization (deepened voice, hirsutism, clitoral enlargement, menstrual disruption), hepatic injury (transaminitis, cholestasis, peliosis, liver tumour), cardiovascular events (MI, stroke, atherosclerosis) & adverse lipids. Use caution if any of these apply to you: Anyone seeking it for body composition or athletic performance — a DEA Schedule III controlled substance with no legitimate medical use; possession/use without a prescription is illegal, and it is not a dietary supplement; Women and adolescents — documented irreversible virilization; the GDR program's worst harms fell on women and underage girls; Pre-existing liver disease or elevated liver enzymes — 17α-alkylated and hepatotoxic (transaminitis, cholestasis, peliosis, liver-tumour risk).
A sympathomimetic stimulant — the 'E' in the ECA (ephedrine/caffeine/aspirin) fat-loss stack. Ephedrine plus caffeine genuinely produces MODEST fat loss in 6-month RCTs (~0.9 kg/month more than placebo, ~3 kg over a controlled diet trial). But that is the whole upside: ephedra alkaloids were BANNED from US dietary supplements in 2004 after the FDA tied them to cardiovascular and psychiatric harms and deaths (the JAMA meta-analysis found a 2.2–3.6× increase in psychiatric/autonomic/GI symptoms and palpitations). Pharmaceutical ephedrine survives only as a restricted behind-the-counter decongestant/vasopressor. NOT a dietary supplement, NOT a longevity drug — a gated harm-reduction entry.
Stacking androgenic agents compounds hepatic burden, HPTA suppression and the adverse lipid shift; the combined risk is additive and uncharacterised in non-medical use.