We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies

Ump3.0

Uridine Monophosphate Research

Mostly mechanism / observationalModerate safety

5 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Uridine Monophosphate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 2008–2025.

Based on 5 studies · 2 RCTs

Confidence

Low confidence

By outcome

Cognitive functionSmall memory benefit in mild Alzheimer's — but only as part of the uridine + DHA + choline combination (Souvenaid), not standalone UMP · Unknown for standalone; 12-24 weeks in combination trials
Too few graded studies4 studies

Active research area

2 studies in the last 5 years

200820162025

1RCT2025

In plain English: As a proof of principle, we developed a practical approach for predicting an individual's alertness impairment using passively recorded facial videos.

Subramaniyan M, Vital-Lopez FG, Doty TJ, Anlap I, Killgore WDS, Reifman J. · Sleep (2025)

Conclusions As a proof of principle, we developed a practical approach for predicting an individual's alertness impairment using passively recorded facial videos.

View source

2Observational2024

In plain English: The use of dietary supplement Neururidine N is an effective and safe method of coanalgesic therapy in patients with acute LBP.

Yakupov EZ, Burd SG, Barantsevich ER, Gamieva RA, Mendel OI, Lebedeva AV, Rubleva YV, Pantina NV, Bokitko TA, Kovaleva II, Bogomazova MA, Efimenko AP, Smochilin AG. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)

In patients of group 1, an earlier improvement in functional status was noted (starting from day 7) according to ORM data ( p <0.01), A more pronounced decrease in pain intensity allowed patients of group 1 to stop taking NSAIDs after 14 days ( p <0.01).
Patients of the 1 st group were statistically significantly more satisfied with the results of treatment (CGI questionnaire), the doctors who observed them also regarded the improvement in their condition as more significant compared to the 2 nd group.
Results The positive effect of treatment on reducing the severity of pain was noted according to the results of the VAS assessment.

View source

3RCTCited 29×2017

In plain English: In patients with mild AD, effect sizes were 0.21 (95% confidence intervals: -0.06, 0.49) for the primary outcome in Souvenir II (neuropsychological test battery memory z-score) and 0.20 (0.10, 0.34) for the co-primary outcome of Souvenir I (Wechsler memory scale delayed recall).

Cummings J, Scheltens P, McKeith I, et al. · J Alzheimers Dis (2017)

Effect-size re-analysis of the three randomised trials of the Souvenaid combination in Alzheimer's dementia (Souvenir I, Souvenir II, S-Connect) plus an open-label extension, not a pooled meta-analysis
Mild AD: effect size 0.20 (95% CI 0.10 to 0.34) on delayed recall in Souvenir I, and 0.21 (95% CI -0.06 to 0.49) on the memory z-score in Souvenir II, an interval that includes no effect
No effect on cognition in mild-to-moderate AD (S-Connect)

View source Free full text

4AnimalCited 47×2008

In plain English: We observe that giving IC rats either dietary UMP or gavaged DHA improves performance on the hidden version of the Morris water maze (all P<0.05), a hippocampal-dependent task; co-administration of both phosphatide precursors further enhances the IC rats' performance on this task (P<0.001).

Holguin S, Huang Y, Liu J, Wurtman R. · Behav Brain Res (2008)

Rats reared in an impoverished environment: dietary UMP (0.5% of the diet) or gavaged DHA (300 mg/kg) each improved hidden-platform water-maze performance (p < 0.05), and the two together improved it further (p < 0.001)
Neither compound, alone or together, changed performance in rats reared in an enriched environment, or on the visible-platform version of the maze, a striatal-dependent task (all p > 0.05)
UMP + DHA increased brain phosphatidylcholine and total phospholipid levels

View source

5AnimalCited 48×2014

In plain English: Only the Fortasyn diet — fish oil plus uridine-monophosphate, choline, B-vitamins and cofactors — alleviated the spatial-learning deficit in Alzheimer-model mice.

Koivisto H, Grimm MO, Rothhaar TL, et al. · J Nutr Biochem (2014)

The Fortasyn combination (including uridine monophosphate) alleviated spatial-learning deficits where fish oil alone did not
Benefit was independent of brain amyloid reduction
Animal model only; tests the combination, not standalone uridine

View source

View in Research Library

Uridine Monophosphate Research

Mostly mechanism / observational

Personalized alertness prediction using video-based ocular and facial features

[The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study)]

Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease.

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats.

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition.