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Ump3.0

Uridine Monophosphate Research

Mostly mechanism / observational

5 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Uridine Monophosphate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality meta-analyses and randomised trials published 2008–2025 with a typical study size of 101 participants.

Based on 5 studies · 1 meta-analysis · 1 RCT · 115 total participants

Confidence

Moderate confidence

By outcome

Cognitive functionSmall memory benefit in mild Alzheimer's — but only as part of the uridine + DHA + choline combination (Souvenaid), not standalone UMP · Unknown for standalone; 12-24 weeks in combination trials
Mostly mechanism / observational4 studies

Active research area

2 studies in the last 5 years · Latest meta-analysis: 2017

200820162025

1RCTn=14 · very small study2025

Subramaniyan M, Vital-Lopez FG, Doty TJ, Anlap I, Killgore WDS, Reifman J. · Sleep (2025)

Conclusions As a proof of principle, we developed a practical approach for predicting an individual's alertness impairment using passively recorded facial videos.

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2Observationaln=101 · medium study2024

In plain English: Conclusion The use of dietary supplement Neururidine N is an effective and safe method of coanalgesic therapy in patients with acute LBP.

Yakupov EZ, Burd SG, Barantsevich ER, Gamieva RA, Mendel OI, Lebedeva AV, Rubleva YV, Pantina NV, Bokitko TA, Kovaleva II, Bogomazova MA, Efimenko AP, Smochilin AG. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)

In patients of group 1, an earlier improvement in functional status was noted (starting from day 7) according to ORM data ( p <0.01), A more pronounced decrease in pain intensity allowed patients of group 1 to stop taking NSAIDs after 14 days ( p <0.01).
Patients of the 1 st group were statistically significantly more satisfied with the results of treatment (CGI questionnaire), the doctors who observed them also regarded the improvement in their condition as more significant compared to the 2 nd group.
Results The positive effect of treatment on reducing the severity of pain was noted according to the results of the VAS assessment.

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3Meta-Analysis2017

In plain English: Across three RCTs, the uridine-monophosphate-containing medical food Souvenaid achieved small but clinically detectable memory effects in mild Alzheimer's, with no cognitive effect in mild-to-moderate disease.

Cummings J, Scheltens P, McKeith I, et al. · J Alzheimers Dis (2017)

Effect size ~0.20-0.21 on memory outcomes in mild AD (Souvenir I and II)
No effect on cognition in mild-to-moderate AD (S-Connect)
Effect is for the COMBINATION (uridine monophosphate + DHA + EPA + choline + phospholipids + B-vitamins), not standalone uridine

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4Animal2008

In plain English: In memory-impaired rats, dietary uridine monophosphate or DHA improved water-maze performance, and combining the two enhanced it further while raising brain phospholipid levels.

Holguin S, Huang Y, Liu J, Wurtman R. · Behav Brain Res (2008)

Dietary UMP or gavaged DHA each improved hippocampal-dependent memory in impoverished rats (p < 0.05)
Co-administration of UMP + DHA further enhanced performance (p < 0.001)
UMP + DHA increased brain phosphatidylcholine and total phospholipid levels

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5Animal2014

In plain English: Only the Fortasyn diet — fish oil plus uridine-monophosphate, choline, B-vitamins and cofactors — alleviated the spatial-learning deficit in Alzheimer-model mice.

Koivisto H, Grimm MO, Rothhaar TL, et al. · J Nutr Biochem (2014)

The Fortasyn combination (including uridine monophosphate) alleviated spatial-learning deficits where fish oil alone did not
Benefit was independent of brain amyloid reduction
Animal model only; tests the combination, not standalone uridine

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View in Research Library

Uridine Monophosphate Research

Mostly mechanism / observational

Personalized alertness prediction using video-based ocular and facial features

[The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study)]

Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease.

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats.

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition.