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Ver4.6
Verapamil Research
Mostly mechanism / observational
643 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Verapamil studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1975–2026 with a typical study size of 1,434 participants.
Based on 643 studies · 20 meta-analyses · 614 RCTs · 3,545 total participants
Confidence
High confidence
By outcome
Heart & blood pressureDecades-established control of hypertension, angina, and supraventricular arrhythmias via vascular and AV-node effects · Hours to weeks
Mostly mechanism / observational338 studies
Type-1 diabetes & beta-cell functionRandomized trials in new-onset type 1 diabetes show partial preservation of stimulated C-peptide and lower insulin needs (adjunctive, repurposed) · 3-12 months
Mostly mechanism / observational22 studies
Safety profile
Mostly mechanism / observational4 studies
Slowing down
Only 12 studies in the last 5 years · Latest meta-analysis: 2026
197520002026
1Meta-Analysis2015
Su Q, Nyi TS, Li L · Cochrane Database Syst Rev (2015)