41 peer-reviewed studies · Evidence score: 9/10
Tobias DK et al. • Nature communications (2025)
This meta-analysis examined the effects of Omega-3.
Fedora K et al. • Annals of medicine (2024)
Vitamin D supplementation can lower the occurrence of exacerbations in children with asthma, along with the improvement of FEV1.
Manoj P et al. • International journal of older people nursing (2023)
Daily oral supplementation 800 IU of vitamin D3 plus 1200 mg of calcium reduces hip fracture and non-vertebral fracture in older people.
D'Ecclesiis O et al. • Nutrients (2024)
Vitamin D may play a protective role in COVID-19, particularly in those with deficiency.
Lin KC et al. • Nutrients (2024)
In conclusion, although substantial heterogeneity persists, vitamin D supplementation decreased pain intensity in patients with dysmenorrhea, especially in those with primary dysmenorrhoea.
Ma K et al. • Nutrients (2021)
Vitamin D supplementation during pregnancy or infancy may be associated with reduced adiposity in childhood.
Bortolussi-Courval É et al. • Basic & clinical pharmacology & toxicology (2024)
Limited direct evidence supports a switch from daily to weekly cholecalciferol dosing; however, weekly supplementation was not demonstrably worse at repleting levels and decreased a patient's daily pill burden.
Luo T et al. • PloS one (2022)
Vitamin D supplementation during pregnancy may be associated with increased humeral length (HL) in the uterus, increased body length at birth and higher cord blood 25(OH)D concentration.
Martineau AR et al. • BMJ (2017)
Vitamin D supplementation reduced the risk of acute respiratory tract infection, with stronger effects in those with profound deficiency.
Anglin RE et al. • British Journal of Psychiatry (2013)
Low vitamin D levels are associated with depression, and supplementation may improve symptoms in deficient individuals.
Stockton KA et al. • Osteoporosis International (2011)
Vitamin D supplementation improves muscle strength, particularly in individuals with baseline vitamin D deficiency.
Perna S • Medicina (Kaunas, Lithuania) (2019)
Conclusions: This meta-analysis lays the foundation for defining the potential clinical efficacy of vitamin D supplementation as a potential therapeutic option for weight loss programs, but further studies are needed to confirm the validity of these findings and delineate potential underlying mechanisms.
Langlois PL et al. • Clinical nutrition (Edinburgh, Scotland) (2018)
In critically ill patients, Vitamin D administration does not improve clinical outcomes.
Diao N et al. • Clinical biochemistry (2017)
The results of this study indicate that vitamin D supplementation may not have a clinically significant effect on pain control or structure progression among patients with knee OA.
Fang F et al. • Complementary therapies in clinical practice (2017)
Evidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS.
Kawada K et al. • Medicina (Kaunas, Lithuania) (2025)
Conclusions: The study results suggest that vitamin D supplementation alleviates allergic rhinitis symptoms, although the effects differ according to the patient's sex and concomitant medications.
Hu L et al. • Nutrition reviews (2025)
According to our findings, vitamin D has a significant effect on hypertriglyceridemia in individuals who are overweight or obese.
Bouillon R et al. • Endocrine Reviews (2023)
Vitamin D supplementation does not benefit bone or reduce fractures in vitamin D-replete adults, but correcting deficiency is essential.
Mikola T et al. • Critical reviews in food science and nutrition (2023)
Results for main outcome (n = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges' g = -0.317, 95% CI [-0.405, -0.230], p < 0.001, I2 = 88.16%; GRADE: very low certainty).
van den Heuvel EG et al. • Advances in nutrition (Bethesda, Md.) (2024)
Vitamin D3 leads to a greater increase of 25(OH)D than vitamin D2, even if limited to daily dose studies, but vitamin D2 and vitamin D3 had similar positive impacts on their corresponding 25(OH)D hydroxylated forms.