Vitamin K1 Research

Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.

Dashti HS, Shea MK, Smith CE, Tanaka T, Hruby A, Richardson K · Am J Clin Nutr (2014)

Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.

Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ · Arch Intern Med (2006)

Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.

Shea MK, Barger K, Booth SL, Matuszek G, Cushman M, Benjamin EJ · Am J Clin Nutr (2020)

Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis.

Dezee KJ, Shimeall WT, Douglas KM, Shumway NM, O'malley PG · Arch Intern Med (2006)

The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review

In plain English: More research related to synergism and the possible mechanisms of vitamins D3 and K interaction in bone health is needed.

Aaseth JO, Finnes TE, Askim M, Alexander J. · Nutrients (2024)

Vitamin K: Metabolism, Genetic Influences, and Chronic Disease Outcomes

In plain English: This review aims to (i) provide an overview of the structure, dietary sources, metabolism, and physiological roles of vitamin K, including those relating to; cardiovascular diseases, type 2 diabetes, respiratory conditions, musculoskeletal health and cancer; (ii) discuss the impact of genetic factors on vitamin K status and how such factors modulate the role of vitamin K in the aforementioned chronic diseases; and (iii) outline key directions for future research.

Dupuy M, Bondonno NP, Pokharel P, Linneberg A, Levinger I, Schultz C, Hodgson JM, Sim M. · Food science & nutrition (2025)

Reversal of excessive oral anticoagulation with a low oral dose of vitamin K1 compared with acenocoumarine discontinuation. A prospective, randomized, open study.

Fondevila CG, Grosso SH, Santarelli MT, Pinto MD · Blood Coagul Fibrinolysis (2001)

Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease.

Ibarrola-Jurado N, Salas-Salvadó J, Martínez-González MA, Bulló M · Am J Clin Nutr (2012)

Effect of phylloquinone supplementation on glucose homeostasis in humans.

Kumar R, Binkley N, Vella A · Am J Clin Nutr (2010)

Vitamin K1 supplementation to improve the stability of anticoagulation therapy with vitamin K antagonists: a dose-finding study.

Gebuis EP, Rosendaal FR, van Meegen E, van der Meer FJ · Haematologica (2011)

Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study.

Braam LA, Hoeks AP, Brouns F, Hamulyák K, Gerichhausen MJ, Vermeer C · Thromb Haemost (2004)

Vitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trial.

Chawla D, Deorari AK, Saxena R, Paul VK, Agarwal R, Biswas A · Indian Pediatr (2007)

Vitamin K1 in oral solution or tablets: a crossover trial and two randomized controlled trials to compare effects.

van Rein N, Gebuis EP, Lijfering WM, Groeneveld JJ, van der Horst FA, le Cessie S · J Thromb Haemost (2014)

Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis.

Shea MK, Booth SL, Miller ME, Burke GL, Chen H, Cushman M · Am J Clin Nutr (2013)

Increase in plasma phylloquinone concentrations following acupoint injection for the treatment of primary dysmenorrhea.

Chao MT, Wade CM, Booth SL · J Acupunct Meridian Stud (2014)

Menaquinone-4 in breast milk is derived from dietary phylloquinone.

Thijssen HH, Drittij MJ, Vermeer C, Schoffelen E · Br J Nutr (2002)

Randomized, placebo-controlled trial of orally administered vitamin K1 for warfarin-associated coagulopathy in Chinese patients with mechanical heart valves.

Zhang H, Li M, Ao XL, Dong YJ, Dong L · Eur J Clin Pharmacol (2021)

Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.

Drury D, Grey VL, Ferland G, Gundberg C, Lands LC · J Cyst Fibros (2008)

Vitamin K intake and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial.

Hoyt M, Reger M, Marley A, Fan H, Liu Z, Zhang J · Am J Clin Nutr (2019)

EVITA-a double-blind, vehicle-controlled, randomized phase II trial of vitamin K1 cream as prophylaxis for cetuximab-induced skin toxicity.

Hofheinz RD, Lorenzen S, Trojan J, Ocvirk J, Ettrich TJ, Al-Batran SE · Ann Oncol (2018)