A randomized trial found vitamin K1 added to bisphosphonate did NOT significantly change BMD or bone turnover; only a modest per-protocol effect on hip geometry.
Moore AE et al. · Arch Osteoporos (2023)
- NO significant effect on bone density (BMD) or bone-turnover markers vs placebo
- 3-arm trial (K1 / MK-4 / placebo), ~35 per arm; only a modest per-protocol effect on hip geometry
- Bone benefit of supplemental K1 is minimal