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Wheatgrass (Triticum aestivum)
The young grass of the common wheat plant, juiced or powdered as a chlorophyll- and nutrient-rich 'green' tonic. A few small clinical trials hint at benefits — reduced disease activity in distal ulcerative colitis and lower transfusion needs in some thalassemia patients — but every trial is small and methodologically limited, and most other claims rest on in-vitro and animal work.
What the evidence says
Most Wheatgrass studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2002–2026 with a typical study size of 23 participants.
Based on 7 studies · 1 RCT · 39 total participants
Confidence
Low confidenceBy outcome
Only a few small human trials exist, with most claims resting on preclinical work, so wheatgrass scores low despite intriguing early signals in ulcerative colitis and thalassemia.
2 trials ongoing or recruiting · 1 completed on ClinicalTrials.gov
Registered trials show research momentum for Wheatgrass, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Sep 2026
Wheatgrass is the young, grass-stage shoots of Triticum aestivum, harvested before the plant forms grain and consumed as fresh juice, frozen juice, tablets or powder. Its marketing leans on a rich content of chlorophyll, flavonoids, and vitamins C and E, with broad 'detox' and 'energy' claims.
The honest evidence picture: there are a handful of small human trials with intriguing but preliminary signals — a randomized double-blind placebo-controlled trial in active distal ulcerative colitis (23 patients) found reduced disease activity and rectal bleeding, and a pilot study in transfusion-dependent beta-thalassemia found roughly half of patients needed less blood.
Beyond these, most evidence is in-vitro (often using the distinct fermented wheat germ extract) or animal work on antioxidant, anti-cancer-adjuvant and gastroprotective effects.
Reviews of the field consistently conclude that the trials are small, have methodological problems, and that benefits need confirmation in larger studies before any clinical recommendation. So wheatgrass sits firmly in 'emerging, plausible-but-unproven' territory.
Rich in chlorophyll, flavonoids and vitamins C/E, with antioxidant activity shown in lab assays.
Preclinical work links wheatgrass flavonoids (e.g. schaftoside) to mucin-protective pathways in cell and animal models.
How Wheatgrass works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Use caution — verify the product is certified gluten-free, as seed/grain cross-contamination is possible.
Not studied; raw juice also carries a contamination risk — avoid raw forms in pregnancy.
No clinically significant drug interactions are well documented; data are limited. This possible interaction has not been individually evaluated for this supplement; its likelihood and severity are unknown. If you take an anticoagulant or antiplatelet medicine, ask a pharmacist or prescriber before using this product. Do not stop or change prescribed medicines based on this notice.
Tip: Start with a small amount; dilute the juice
The current evidence for Wheatgrass is insufficient to assign an evidence score, based on 7 indexed studies. The young grass of the common wheat plant, juiced or powdered as a chlorophyll- and nutrient-rich 'green' tonic. A few small clinical trials hint at benefits — reduced disease activity in distal ulcerative colitis and lower transfusion needs in some thalassemia patients — but every trial is small and methodologically limited, and most other claims rest on in-vitro and animal work. Representative study: PMID 11989836.
The commonly studied dose of Wheatgrass is About 100ml of fresh wheatgrass juice daily (dose used in the UC and thalassemia trials); powders ~3-5g. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Wheatgrass is in the morning. It can be taken on an empty stomach. Traditionally taken on an empty stomach as juice; trials used ~100ml/day.
Wheatgrass is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are nausea, headache, or unpleasant taste (tolerability). Use caution if any of these apply to you: Wheat or grass allergy; Celiac disease / gluten sensitivity (grass is harvested pre-grain but cross-contamination with seed is possible).
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 7 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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