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Wy6.0
Wild Yam Research
Probably helpsHigh safety
12 peer-reviewed studies
What the evidence says
Probably helps
Wild Yam helped in about half (2/3) of the studies that measured an effect — promising, but not unanimous.
Most evidence is from high-quality randomised trials published 2001–2021 with a typical study size of 96 participants.
Based on 12 studies · 2 RCTs · 269 total participants
Confidence
Low
What the studies found
2helped1unclear· 9 more without graded effect data
By outcome
Menopause & hormonalMay help manage menopausal symptoms like hot flashes and mood changes · 4-8 weeks · Supports healthy estrogen metabolism and hormonal equilibrium · 4-8 weeks · May help reduce menstrual discomfort and PMS symptoms · 1-3 cycles
Probably helps11 studies
Therapeutic & clinical
Mostly mechanism / observational3 studies
Bone health
Too few graded studies2 studies
Heart & blood pressure
Too few graded studies1 study
Cholesterol & lipids
Too few graded studies1 study
Depression & moodSupport for hormonal balance and menopausal symptoms · 4-8 weeks
Too few graded studies1 study
Cognitive function
Too few graded studies1 study
Inflammation
Too few graded studies1 study
Longevity & aging
Too few graded studies1 study
By the numbers
Pulled from 10 studies with measurable effects
People studied
269
typical study: 96 people
Strongest designs
2
0 pooled, 2 randomised
Showed benefit
67%
2/3 studies
Populations Studied
Menopausal women6
General population with hormonal conditions1
Cardiovascular disease patients1
Triple-negative breast cancer patients1
Slowing down
Only 1 study in the last 5 years
200120112021
1Systematic ReviewCited 75×n=150 · medium study2020
Keywords related to glioma, ischemia, memory, aging, cognitive impairment, Alzheimer, Parkinson, and neurodegenerative disorders were searched in the databases based on DG and its derivatives.
Cai B et al. · Oxidative medicine and cellular longevity (2020)
Three independent researchers examined articles for eligibility.
A total of 150 articles were screened from the above scientific literature databases.
Finally, a total of 46 articles were extracted and included in this review.
The results of RCTs of the hop flavonoid 8-prenylnaringenin are conflicting.
Depypere HT et al. · Maturitas (2014)
The results of RCTs of the hop flavonoid 8-prenylnaringenin are conflicting.
Animal and human studies suggest that Dioscorea villosa (Wild yam),and Broccoli may protect against osteoporosis and breast and gynecological cancers but further evidence is required.
Linseed may protect against breast cancer but the results are conflicting.
It is noteworthy that newly synthesized DSG derivatives and DSG delivery systems have good antithrombotic activity and pharmacokinetic characteristics.
Wu FC et al. · Food & function (2019)
Numerous preclinical studies have shown that DSG has great potential in the treatment of various cardiovascular diseases in vivo and in vitro, especially in atherosclerosis.
This review mainly discusses the effects of DSG on endothelial dysfunction, lipid profile, and macrophage foam cell formation, VSMC viability, thrombosis and inflammation during the formation of atherosclerosis.
Also, the mechanism of DSG on atherosclerosis was elaborated in detail.
Future larger and better controlled studies testing the effectiveness of these treatments are needed.
Shou C et al. · Chinese journal of integrative medicine (2011)
An increased number of women seek the use of complementary and alternative medicine (CAM) for treating menopausal symptoms.
This review analyzes the evidence from systematic reviews, randomized controlled trials and epidemiological studies of using herbal medicine (Black cohosh, Dong quai, St John's wart, Hops, Wild yam, Ginseng, and evening primrose oil) and acupuncture for the treatment of menopausal symptoms.
Evidence supporting the efficacy and safety of most CAM for relief of menopausal symptoms are limited.
Selective serotonin reuptake inhibitors and venlafaxine have been shown to reduce hot flashes by 19 to 60 percent and were well tolerated by study participants.
Soy isoflavones reduced hot flashes by 9 to 40 percent in some trials, but most trials showed no difference compared with placebo.
Black cohosh and red clover also have had inconsistent results, with some trials showing benefit and some no difference compared with placebo.
A critical review of the literature shows that progesterone may have an independent effect on relieving hot flashes.
Haimov-Kochman R et al. · Acta obstetricia et gynecologica Scandinavica (2005)
A critical review of the literature shows that progesterone may have an independent effect on relieving hot flashes.
New nonhormonal agents such as selective serotonin-uptake-inhibitor anti-depressants and a new anti-convulsant gabapentin yielded promising results on small well-conducted studies.
Isoflavone's effect on hot flashes is variable and inconsistent, and only modest and delayed improvement of symptoms could be expected by BC and vitamin E.
12Cellular invasion reduction in MDA-MB-231 breast cancer cellsIn VitroCited 49×2016
We propose that DS has potential to be used as an anti-invasive agent in breast cancer.
Aumsuwan P et al. · Archives of biochemistry and biophysics (2016)
Huge benefit
← WorseNo effectBetter →
Cellular invasion of MDA-MB-231 was reduced by 65 ± 5% in the presence of 5.76 μM DS.
DS (5.76 μM)-treated MDA-MB-231 cells exhibited the morphological characteristic of epithelial-like cells; mRNA expression of DNMT3A, TET2, TET3, ZFPM2 and E-cad were increased while TET1, VIM and MMP9 were decreased.
Our data suggested that DS-mediated pathway could promote GATA3 expression at transcription and translation levels.