Zinc Carnosine

Riley P et al. • The Cochrane database of systematic reviews (2017)

“There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy).”

Key Findings:

There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy).
However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy.
The benefits of amifostine should be weighed against its high cost and side effects.
There was insufficient evidence to show that any other intervention is beneficial.

📚meta-analysis

Sureshkumar K et al. • Frontiers in bioscience (Landmark edition) (2023)

“Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.”

Key Findings:

Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.
Further research warranted to confirm findings

📚meta-analysisn=396

Mahmoud A et al. • Nutrients (2022)

“However, the evidence is still scarce, and larger trials are needed to confirm or refute our findings.”

Key Findings:

We used the odds ratio (OR) for dichotomous outcomes presented with the corresponding 95% confidence interval (CI).
Pooled OR found a statistical difference favoring the PZN arm in the intention to treat and per protocol H. pylori eradication rates (OR: 2.01 with 95% CI [1.27, 3.21], p = 0.003) and (OR: 2.65 with 95% CI [1.55, 4.54], p = 0.0004), respectively.
We found no statistical difference between the two groups regarding the total adverse events (OR: 1.06 with 95% CI [0.55, 2.06], p = 0.85).

📚meta-analysis

Furihata K et al. • Nutrients (2020)

“The dose of 300 mg may be useful among patients with baseline serum zinc concentration of less than 70 µg/dL, and 150 mg for 70 µg/dL or more.”

Key Findings:

The dose-combined overall polaprezinc increased the change from baseline by a mean of 9.08 µg/dL (95% confidence interval: 5.46, 12.70; heterogeneity: I2 = 0.61%) compared to the placebo.
A significant dose-response relationship was confirmed (p < 0.001).
Baseline serum zinc concentration was considered an effect modifier in polaprezinc 300 mg.
All doses of polaprezinc were tolerable, but a dose-response relationship with adverse events (AEs) was observed in gastrointestinal disorders.

📊rctn=24

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Xiao M et al. • Clinical and translational science (2025)

“Clinical and Translational Science”

Key Findings:

The geometric mean ratios (GMR) in primary PK endpoints between the test and reference products with 90% confidence intervals (CI) were calculated.
All 90% CIs of GMRs in Cmax, AUC0-t and AUC0-∞ between the two products were within 80.0%-125.0%.
The generic and original polaprezinc granules were bioequivalent by pharmacokinetic comparisons in healthy Chinese subjects under fasting and fed conditions.
The two polaprezinc formulations were well-tolerated with no new safety signals.

View all 38+ studies

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Zinc Carnosine

compound

Zinc L-Carnosine (Polaprezinc)

Chelated zinc that adheres to damaged stomach tissue, accelerating ulcer healing and protecting gut lining from NSAID damage.

bodygut healthgut barrierulcerszinc

38+ studies

Evidence

Reviewed 19 days ago

high

Safety

75-150mg daily (providing ~16-34mg zinc)

Dose

4-8 weeks

Time to Effect

Zinc L-Carnosine capsules

Best Form

Mechanisms of Action

🛡️

Mucosal Protection

Adheres to and protects damaged stomach lining

⚡

Antioxidant

Reduces oxidative stress in the gut

🦠

H. pylori Support

May help with H. pylori treatment

Biological PathwayBeta

How Zinc Carnosine works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Supplement

Molecular Target

Biological Process

Health Outcome

Strong

Moderate

Emerging

strong

moderate

emerging

Tap node to isolate • Pinch to zoom • Tap edge for research

Recommended Dose

75-150mg daily (providing ~16-34mg zinc)

75mg150mg

Loading: Not required

Optimal Timing

Between meals on empty stomach
Twice daily for ulcer healing

Can be taken without food

Available Forms

Form	Type
💊Zinc L-Carnosine capsules	Recommended
💊PepZin GI (branded form)	Alternative

PepZin GI is the branded, researched form. Generic versions should be chelated zinc-carnosine, not just zinc + carnosine mixed together.

Duration

Minimum: 4 weeks

Optimal: 8 weeks

Cycling: Use for 8 weeks for healing, then reassess. Can use as needed.

Note: Works best on empty stomach to allow direct contact with stomach lining. Divide into 2 doses for optimal effect.

🩹

Ulcer Healing

Accelerates healing of gastric ulcers

⏱️ 4-8 weeks

75% of users notice thispositive

🧱

Gut Barrier Repair

Improves intestinal permeability

⏱️ 4-8 weeks

70% of users notice thispositive

💊

NSAID Protection

Reduces gut damage from NSAIDs

📅 During use

65% of users notice thispositive

High SafetyMax safe dose: 150mg/day of zinc-carnosine

🟡

Those on NSAIDs

Good protective option

Who Should NOT Take This

Known allergy or hypersensitivity to Zinc Carnosine or related compounds

Drug Interactions

Antibiotics (quinolones, tetracyclines)mild

Zinc can reduce absorption; separate by 2 hours

Possible Side Effects

Copper deficiency (long-term high dose)

moderateuncommon

Tip: Don't exceed 8 weeks without break; consider copper supplementation

Warnings

Don't use long-term without breaks (zinc accumulation)
Separate from antibiotics by 2 hours

⟡ L-Glutamine

complementary

Both support gut barrier integrity

Enhanced gut healing and barrier repair

Top studies from 38+ peer-reviewed papers

📚meta-analysisn=3520

Riley P et al. • The Cochrane database of systematic reviews (2017)

“There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy).”

Key Findings:

There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy).
However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy.
The benefits of amifostine should be weighed against its high cost and side effects.
There was insufficient evidence to show that any other intervention is beneficial.

📚meta-analysis

Sureshkumar K et al. • Frontiers in bioscience (Landmark edition) (2023)

“Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.”

Key Findings:

Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.
Further research warranted to confirm findings

📚meta-analysisn=396

Mahmoud A et al. • Nutrients (2022)

“However, the evidence is still scarce, and larger trials are needed to confirm or refute our findings.”

Key Findings:

We used the odds ratio (OR) for dichotomous outcomes presented with the corresponding 95% confidence interval (CI).
Pooled OR found a statistical difference favoring the PZN arm in the intention to treat and per protocol H. pylori eradication rates (OR: 2.01 with 95% CI [1.27, 3.21], p = 0.003) and (OR: 2.65 with 95% CI [1.55, 4.54], p = 0.0004), respectively.
We found no statistical difference between the two groups regarding the total adverse events (OR: 1.06 with 95% CI [0.55, 2.06], p = 0.85).

📚meta-analysis

Furihata K et al. • Nutrients (2020)

“The dose of 300 mg may be useful among patients with baseline serum zinc concentration of less than 70 µg/dL, and 150 mg for 70 µg/dL or more.”

Key Findings:

The dose-combined overall polaprezinc increased the change from baseline by a mean of 9.08 µg/dL (95% confidence interval: 5.46, 12.70; heterogeneity: I2 = 0.61%) compared to the placebo.
A significant dose-response relationship was confirmed (p < 0.001).
Baseline serum zinc concentration was considered an effect modifier in polaprezinc 300 mg.
All doses of polaprezinc were tolerable, but a dose-response relationship with adverse events (AEs) was observed in gastrointestinal disorders.

📊rctn=24

Compare with Others Find Based on Your Goals

Xiao M et al. • Clinical and translational science (2025)

“Clinical and Translational Science”

Key Findings:

The geometric mean ratios (GMR) in primary PK endpoints between the test and reference products with 90% confidence intervals (CI) were calculated.
All 90% CIs of GMRs in Cmax, AUC0-t and AUC0-∞ between the two products were within 80.0%-125.0%.
The generic and original polaprezinc granules were bioequivalent by pharmacokinetic comparisons in healthy Chinese subjects under fasting and fed conditions.
The two polaprezinc formulations were well-tolerated with no new safety signals.

View all 38+ studies

What would you like to do next?

Related Supplements

Clm7.5

Colostrum

First milk rich in immunoglobulins, growth factors, and antimicrobial compounds that supports gut health, immunity, and recovery.

LF7.5

Lactoferrin

A multifunctional iron-binding glycoprotein from milk with broad antimicrobial, anti-inflammatory, and immune-modulating properties.

Lt8.5

Luteolin

Crosses the blood-brain barrier to reduce neuroinflammation and inhibits mast cell activation — useful for allergies and brain health.

Tud8.5

TUDCA