1Meta-Analysis2021
Sun Y, Ma H, Yang F, Tang X, Yi P, Tan M · Biomed Res Int (2021)
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194 peer-reviewed studies
What the evidence says
Most Zoledronate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 109 participants.
Based on 194 studies · 17 meta-analyses · 140 RCTs · 102,821 total participants
Confidence
High confidenceBy outcome
61 studies in the last 5 years · Latest meta-analysis: 2026
Sun Y, Ma H, Yang F, Tang X, Yi P, Tan M · Biomed Res Int (2021)
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Jiang L, Cui X, Ma H, Tang X · J Orthop Surg Res (2021)
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Mei M, Xiang Z, Yang J, Xiang R · Curr Probl Cancer (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Wu C, Chen W, Wu J, Zhang X, Huang X, Lin R · Clin Exp Metastasis (2019)
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He B, Zhao JQ, Zhang MZ, Quan ZX · Eur Rev Med Pharmacol Sci (2021)
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He Y, Bao W, Wu XD, Huang W, Chen H, Li Z · Biomed Res Int (2019)
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Chen C, Li R, Yang T, Ma L, Zhou S, Li M · Clin Ther (2020)
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Li K, Gong H, Xie R, Gu J, Wang S, Lin C · Medicine (Baltimore) (2021)
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Chen J, Zhou L, Liu X, Wen X, Li H, Li W · Int J Clin Pharm (2021)
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Sato J, Kodaira M, Harada H, Iguchi H, Yoshida T, Shibata H · J Oncol Pharm Pract (2024)
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Santini D, Galvano A, Pantano F, Incorvaia L, Rizzo S, Vincenzi B · Crit Rev Oncol Hematol (2019)
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Tang B, Zeng H, Hu S, Liu K, Wu L, Shi X · World Neurosurg (2022)
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Wu XG, Zhang DY, Zhu BQ, Li AM · Eur Rev Med Pharmacol Sci (2020)
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Hu Z, Tian Y, Li W, Ruan Y, Zeng F · Support Care Cancer (2020)
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Pijnenburg L, Salem JE, Lebrun-Vignes B, Sibilia J, Javier RM, Arnaud L · Eur J Endocrinol (2021)
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In plain English: Level of evidence Level I, therapeutic study.
Lan Z, Lin X, Xue D, Yang Y, Saad M, Jin Q. · Clinical orthopaedics and related research (2025)
Mahmoud I, Bouden S, Sahli M, Rouached L, Ben Tekaya A, Tekaya R · J Pediatr Orthop B (2024)
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In plain English: Conclusions Ten years after trial initiation, zoledronate administered at baseline and 5 years was effective in preventing morphometric vertebral fracture in early postmenopausal women. (Funded by the Health Research Council of New Zealand; Australian New Zealand Clinical Trials Registry number, ACTRN12612000270819.).
Bolland MJ, Nisa Z, Mellar A, Gasteiger C, Pinel V, Mihov B, Bastin S, Grey A, Reid IR, Gamble G, Horne A. · The New England journal of medicine (2025)
Zhou W, Liu Y, Guo X, Yang H, Xu Y, Geng D · Osteoporos Int (2019)
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Wilson C, Bell R, Hinsley S, Marshall H, Brown J, Cameron D · Eur J Cancer (2018)
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