1Meta-Analysis2021
Sun Y, Ma H, Yang F, Tang X, Yi P, Tan M · Biomed Res Int (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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207 peer-reviewed studies
What the evidence says
Zoledronate doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 83 participants.
Based on 207 studies · 20 meta-analyses · 147 RCTs · 38,776 total participants
Confidence
High confidenceBy outcome
74 studies in the last 5 years · Latest meta-analysis: 2026
Sun Y, Ma H, Yang F, Tang X, Yi P, Tan M · Biomed Res Int (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Jiang L, Cui X, Ma H, Tang X · J Orthop Surg Res (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mei M, Xiang Z, Yang J, Xiang R · Curr Probl Cancer (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Wu C, Chen W, Wu J, Zhang X, Huang X, Lin R · Clin Exp Metastasis (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
He B, Zhao JQ, Zhang MZ, Quan ZX · Eur Rev Med Pharmacol Sci (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
He Y, Bao W, Wu XD, Huang W, Chen H, Li Z · Biomed Res Int (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Chen C, Li R, Yang T, Ma L, Zhou S, Li M · Clin Ther (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Li K, Gong H, Xie R, Gu J, Wang S, Lin C · Medicine (Baltimore) (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Chen J, Zhou L, Liu X, Wen X, Li H, Li W · Int J Clin Pharm (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Sato J, Kodaira M, Harada H, Iguchi H, Yoshida T, Shibata H · J Oncol Pharm Pract (2024)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Santini D, Galvano A, Pantano F, Incorvaia L, Rizzo S, Vincenzi B · Crit Rev Oncol Hematol (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tang B, Zeng H, Hu S, Liu K, Wu L, Shi X · World Neurosurg (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Wu XG, Zhang DY, Zhu BQ, Li AM · Eur Rev Med Pharmacol Sci (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hu Z, Tian Y, Li W, Ruan Y, Zeng F · Support Care Cancer (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: These findings should be interpreted with caution as some analyses suffered from statistical imprecision.
Moshi MR et al. · Calcified tissue international (2023)
Pijnenburg L, Salem JE, Lebrun-Vignes B, Sibilia J, Javier RM, Arnaud L · Eur J Endocrinol (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Based on our comprehensive meta-analysis, there is high-quality evidence suggesting that bisphosphonate therapy for patients with osteoporosis does not reduce the overall risk of mortality despite its effectiveness in reducing the risk of fractures.
Lan Z, Lin X, Xue D, Yang Y, Saad M, Jin Q. · Clinical orthopaedics and related research (2025)
In plain English: International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.
Kobayashi T et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2024)
Mahmoud I, Bouden S, Sahli M, Rouached L, Ben Tekaya A, Tekaya R · J Pediatr Orthop B (2024)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Ten years after trial initiation, zoledronate administered at baseline and 5 years was effective in preventing morphometric vertebral fracture in early postmenopausal women. (Funded by the Health Research Council of New Zealand; Australian New Zealand Clinical Trials Registry number, ACTRN12612000270819.).
Bolland MJ, Nisa Z, Mellar A, Gasteiger C, Pinel V, Mihov B, Bastin S, Grey A, Reid IR, Gamble G, Horne A. · The New England journal of medicine (2025)