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Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
13 of 14 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
8 of 11 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Aged Garlic Extract and D-Mannose have evidence — compare verdict strength side-by-side.
600-1200mg aged garlic extract
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
2g daily for prevention; 1.5-2g every 2-3 hours for acute symptoms
On empty stomach with water, Before bed (urine stays in bladder longer)
Pure D-Mannose powder
8-12 weeks
12+ weeks
4-8 weeks
Ongoing prevention
24-48 hours
Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials
Prostaglandins & other lipid mediators (2024) · Meta analysis · n=584
AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: -4.03; %95CI: -6.87, -1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: -1.44; 95 % CI= -2.87, -0.02; P = 0.052; I2: 36.8 %; P: 0.105).
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Nonantibiotic prophylaxis for urinary tract infections: a network meta-analysis of randomized controlled trials
Infection (2025) · Meta analysis · n=10495
Nearly 80% of the RCTs utilized double-blind or triple-blind designs.
Efficacy of D-mannose as prophylaxis of recurrent urinary tract infection: a systematic review and meta-analysis of randomized controlled trials
Jornal brasileiro de nefrologia (2025) · Meta analysis · n=1167
We included 6 RCTs comprising 1,167 participants, of whom 534 received D-mannose and 521 (97.6%) were women.
d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial
JAMA internal medicine (2024) · Rct · n=7591
Of 598 women eligible (mean [range] age, 58 [18-93] years), 303 were randomized to d-mannose (50.7%) and 295 to placebo (49.3%).
Meta-analysis shows modest SBP reduction of ~4 mmHg and DBP reduction of ~1.4 mmHg. Effect size is relatively small compared to pharmaceutical interventions. Studies primarily used aged garlic extract forms.
Based on meta-analysis of 6 RCTs (n=1,167) showing mixed results - one large meta-analysis found no significant reduction vs control. Evidence quality limited by heterogeneity in study designs. Conservative effectiveness estimates due to conflicting findings.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For support immune system, D-Mannose has a higher relevance score (95 vs 70).
No known interactions between Aged Garlic Extract and D-Mannose have been documented in our database. However, always consult a healthcare provider before combining supplements.