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Age7.5
Aged Garlic Extract Research
Likely helps
97 peer-reviewed studies
What the evidence says
Likely helps
Aged Garlic Extract appears to help in 14 of 15 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1996–2025 with a typical study size of 65 participants.
Based on 97 studies · 11 meta-analyses · 69 RCTs · 22,204 total participants
Confidence
High confidence
What the studies found
14helped1didn't help· 82 more without graded effect data
By outcome
Heart & blood pressureReduces blood pressure and arterial stiffness in clinical trials · 8-12 weeks
Likely helps40 studies
Therapeutic & clinical
Mostly mechanism / observational13 studies
Cholesterol & lipidsReduces blood pressure and arterial stiffness in clinical trials · 8-12 weeks
Likely helps12 studies
InflammationReduced blood pressure and improved arterial health · 8-12 weeks
Probably helps7 studies
Glucose & metabolic
Mostly mechanism / observational6 studies
Immune supportEnhanced immune cell function · 4-8 weeks
Mostly mechanism / observational5 studies
Safety profile
Mostly mechanism / observational5 studies
By the numbers
Pulled from 47 studies with measurable effects
Likely real effects
86%
across studies
People studied
22k
typical study: 65 people
Strongest designs
80
11 pooled, 69 randomised
Showed benefit
93%
14/15 studies
How long studies ran
1–4 weeks
1
1–3 months
8
3+ months
10
Populations Studied
Hypertensive patients3
Healthy adults2
Patients with metabolic syndrome2
Adults at risk for coronary atherosclerosis2
Steady research
28 studies in the last 5 years · Latest meta-analysis: 2025
199620102025
1Systematic ReviewCited 9×n=9,901 · very large study2023
Currently, there are insufficient or conflicting data for interventions evaluated in clinical trials for mitigation of cardiovascular calcification.
Murali S et al. · Journal of the American Heart Association (2023)
Currently, there are insufficient or conflicting data for interventions evaluated in clinical trials for mitigation of cardiovascular calcification.
Therapy involving aged garlic extract appears most promising, but evaluable studies were small and of short duration.
2Systolic blood pressure reductionMeta-AnalysisCited 6×n=584 · large study2024
The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
Saadh MJ et al. · Prostaglandins & other lipid mediators (2024)
Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.
The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
However, garlic could be considered a safe natural medicine to debilitate inflammation in CAD patients.
Gadidala SK et al. · Phytotherapy research : PTR (2023)
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
In the case of subgroup analysis, the overall effect was significantly effective in reducing TC, LDL levels and improving HDL levels in CV risk patients.
Our study findings provide consistent evidence that intake of garlic reduces CVD risk factors.
9Total cholesterol reductionMeta-AnalysisCited 37×n=26 · very small study2012
Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
Zeng T et al. · Journal of the science of food and agriculture (2012)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
De Greef D et al. · Seminars in cancer biology (2021)
This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
Concerns and limitations that have arisen in past studies regarding standards of measurement, bioavailability, and method of delivery are addressed.
Overall, it is hoped that through this systematic and comprehensive review, future researchers can be acquainted with the updated data assembled on anticancer properties of garlic and its phytoconstituents.
Some nutraceuticals might have a positive impact on BP in humans.
Borghi C et al. · British journal of clinical pharmacology (2017)
Some nutraceuticals might have a positive impact on BP in humans.
Further clinical research is needed, to identify from the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for widespread and long-term use in the general population with a low-added cardiovascular risk related to uncomplicated hypertension.
12C-reactive protein levelsMeta-AnalysisCited 13×n=17 · very small study2020
This meta-analysis showed that supplementation with garlic could reduce the level of circulating CRP and AGE could reduce the level of TNF-α and CRP, whereas it had no significant effect on the IL-6 level.
Mirzavandi F et al. · Diabetes & metabolic syndrome (2020)
Borderline
Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05).
Future research should be aimed at eliciting information on pharmacokinetics, safety, and long-term efficacy of these byproducts from garlic in order to fully appraise them in the clinical field.
Jain M, Patil N, Mohammed A, Hamzah Z. · Journal of food science (2025)
More so, supercritical fluid extraction and ultrasound-assisted methods have improved isolation yields of bioactive compounds with stronger stability.
This review puts emphasis on the biochemical composition and biological properties of garlic byproducts, underlining their use as sustainable and effective natural medicine sources.
The findings have placed an emphasis on the use of garlic byproducts in functional foods and pharmaceutical preparations to deal with global health challenges.
18Colorectal cancer riskSystematic ReviewCited 57×2007
On balance, there is consistent scientific evidence derived from RCT of animal studies reporting protective effects of garlic on CRC despite great heterogeneity of measures of intakes among human epidemiological studies.
Ngo SN et al. · The Journal of nutrition (2007)
Large benefit
← WorseNo effectBetter →
One randomized controlled trial (RCT, level II) reported a statistically significant 29% reduction in both size and number of colon adenomas in CRC patients taking aged garlic extract.
A published meta-analysis (level III) of 7 of these studies confirmed this inverse association, with a 30% reduction in relative risk.
Five of 8 case control/cohort studies (level III) suggested a protective effect of high intake of raw/cooked garlic and 2 of 8 of these studies suggested a protective effect for distal colon.
19Coronary artery calcification progressionRCTCited 33×n=104 · medium study2020
AGE inhibits CAC progression, lowers IL-6, glucose levels and blood pressure in patients at increased risk of cardiovascular events in a European cohort.
Wlosinska M et al. · BMC complementary medicine and therapies (2020)
Huge harm
← WorseNo effectBetter →
Borderline
There was a significant (p < 0.05) change in CAC progression (OR: 2.95 [1.05-8.27]), blood glucose (OR: 3.1 [1.09-8.85]) and IL-6 (OR 2.56 [1.00-6.53]) in favor of the active group.
The AGE Algorithm, at a selected probability cut-off value of 0.5, the accuracy score for CAC progression was 80%, precision score of 79% and recall score 83%.
The score for blood pressure was 74% (accuracy, precision and recall).
Wlosinska M et al. · International wound journal (2019)
Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry.
A repeated measures analysis of variance (ANOVA) with a Greenhouse-Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points.
Increased microcirculation could hypothetically facilitate wound healing.