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Age7.5
Aged Garlic Extract – Forschung
Hilft wahrscheinlich
66 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Aged Garlic Extract scheint in 10 von 10 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1996–2025 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 66 Studien · 7 Meta-Analysen · 41 RCTs · 8,051 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
10geholfen· 56 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureSenkt in klinischen Studien den Blutdruck und die arterielle Steifigkeit · 8-12 weeks
Hilft wahrscheinlich24 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung10 Studien
Cholesterol & lipidsSenkt in klinischen Studien den Blutdruck und die arterielle Steifigkeit · 8-12 weeks
Hilft wahrscheinlich5 Studien
Immune supportVerbesserte Funktion der Immunzellen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
InflammationGesenkter Blutdruck und verbesserte arterielle Gesundheit · 8-12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 32 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
89%
über Studien hinweg
Untersuchte Personen
8,051
typische Studie: 60 Personen
Stärkste Designs
48
7 gepoolt, 41 randomisiert
Zeigte Nutzen
100%
10/10 Studien
Wie lange Studien liefen
1–3 Monate
6
3+ Monate
5
Untersuchte Populationen
Hypertensive patients3
Healthy adults2
Adults at risk for coronary atherosclerosis2
Patients at cardiovascular risk1
Aktives Forschungsgebiet
22 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199620102025
1Systolic blood pressure reductionMeta-Analysen=584 · large study2024
Einfach gesagt: The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
Saadh MJ et al. · Prostaglandins & other lipid mediators (2024)
Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.
The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
4Total cholesterol reductionMeta-Analysen=26 · very small study2012
Einfach gesagt: Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
Zeng T et al. · Journal of the science of food and agriculture (2012)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
Einfach gesagt: This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
De Greef D et al. · Seminars in cancer biology (2021)
This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
Concerns and limitations that have arisen in past studies regarding standards of measurement, bioavailability, and method of delivery are addressed.
Overall, it is hoped that through this systematic and comprehensive review, future researchers can be acquainted with the updated data assembled on anticancer properties of garlic and its phytoconstituents.
Einfach gesagt: Some nutraceuticals might have a positive impact on BP in humans.
Borghi C et al. · British journal of clinical pharmacology (2017)
Some nutraceuticals might have a positive impact on BP in humans.
Further clinical research is needed, to identify from the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for widespread and long-term use in the general population with a low-added cardiovascular risk related to uncomplicated hypertension.
7C-reactive protein levelsMeta-Analysen=17 · very small study2020
Einfach gesagt: This meta-analysis showed that supplementation with garlic could reduce the level of circulating CRP and AGE could reduce the level of TNF-α and CRP, whereas it had no significant effect on the IL-6 level.
Mirzavandi F et al. · Diabetes & metabolic syndrome (2020)
Borderline
Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05).
Einfach gesagt: There is insufficient evidence to determine if garlic … reduc[es] the risk of mortality and cardiovascular morbidity in … hypertension.
Stabler SN et al. · The Cochrane database of systematic reviews (2012)
Insufficient evidence to determine whether garlic reduces mortality and cardiovascular morbidity in patients with hypertension.
Based on two trials in 87 hypertensive patients, garlic reduced mean supine systolic and diastolic blood pressure by roughly 10-12 mmHg and 6-9 mmHg respectively over placebo.
Einfach gesagt: Future research should be aimed at eliciting information on pharmacokinetics, safety, and long-term efficacy of these byproducts from garlic in order to fully appraise them in the clinical field.
Jain M, Patil N, Mohammed A, Hamzah Z. · Journal of food science (2025)
More so, supercritical fluid extraction and ultrasound-assisted methods have improved isolation yields of bioactive compounds with stronger stability.
This review puts emphasis on the biochemical composition and biological properties of garlic byproducts, underlining their use as sustainable and effective natural medicine sources.
The findings have placed an emphasis on the use of garlic byproducts in functional foods and pharmaceutical preparations to deal with global health challenges.
Einfach gesagt: There is insufficient clinical trial evidence regarding the effects of garlic in preventing or treating the common cold.
Lissiman E et al. · The Cochrane database of systematic reviews (2014)
Only one RCT (146 participants, garlic with 180 mg allicin daily vs placebo for 12 weeks) met inclusion criteria for garlic and the common cold.
That single trial suggested garlic may reduce the number of colds, but there is insufficient clinical-trial evidence to determine garlic's effect on preventing or treating the common cold.
14Colorectal cancer riskSystematische Übersicht2007
Einfach gesagt: On balance, there is consistent scientific evidence derived from RCT of animal studies reporting protective effects of garlic on CRC despite great heterogeneity of measures of intakes among human epidemiological studies.
Ngo SN et al. · The Journal of nutrition (2007)
Groß Nutzen
← SchlechterKein EffektBesser →
One randomized controlled trial (RCT, level II) reported a statistically significant 29% reduction in both size and number of colon adenomas in CRC patients taking aged garlic extract.
A published meta-analysis (level III) of 7 of these studies confirmed this inverse association, with a 30% reduction in relative risk.
Five of 8 case control/cohort studies (level III) suggested a protective effect of high intake of raw/cooked garlic and 2 of 8 of these studies suggested a protective effect for distal colon.