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Age9.0
Aged Garlic Extract Research
Likely helpsHigh safety
42 peer-reviewed studies
What the evidence says
Likely helps
Aged Garlic Extract appears to help in 13 of 14 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2024 with a typical study size of 65 participants.
Based on 42 studies · 6 meta-analyses · 31 RCTs · 20,272 total participants
Confidence
High
What the studies found
13helped1didn't help· 28 more without graded effect data
By outcome
Heart & blood pressureReduces blood pressure and arterial stiffness in clinical trials · 8-12 weeks
Likely helps20 studies
Cholesterol & lipidsReduces blood pressure and arterial stiffness in clinical trials · 8-12 weeks
Likely helps8 studies
Therapeutic & clinical
Mostly mechanism / observational7 studies
Glucose & metabolic
Mostly mechanism / observational4 studies
InflammationReduced blood pressure and improved arterial health · 8-12 weeks
Mostly mechanism / observational4 studies
Immune supportEnhanced immune cell function · 4-8 weeks
Mostly mechanism / observational3 studies
Safety profile
Too few graded studies1 study
By the numbers
Pulled from 39 studies with measurable effects
Likely real effects
85%
across studies
People studied
20k
typical study: 65 people
Strongest designs
37
6 pooled, 31 randomised
Showed benefit
93%
13/14 studies
How long studies ran
1–4 weeks
1
1–3 months
7
3+ months
10
Populations Studied
Hypertensive patients3
Healthy adults2
Patients with metabolic syndrome2
Adults at risk for coronary atherosclerosis2
Steady research
10 studies in the last 5 years · Latest meta-analysis: 2024
200520142024
1Systematic ReviewCited 9×n=9,901 · very large study2023
Currently, there are insufficient or conflicting data for interventions evaluated in clinical trials for mitigation of cardiovascular calcification.
Murali S et al. · Journal of the American Heart Association (2023)
Currently, there are insufficient or conflicting data for interventions evaluated in clinical trials for mitigation of cardiovascular calcification.
Therapy involving aged garlic extract appears most promising, but evaluable studies were small and of short duration.
2Systolic blood pressure reductionMeta-AnalysisCited 6×n=584 · large study2024
The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
Saadh MJ et al. · Prostaglandins & other lipid mediators (2024)
Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.
The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day.
However, garlic could be considered a safe natural medicine to debilitate inflammation in CAD patients.
Gadidala SK et al. · Phytotherapy research : PTR (2023)
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
In the case of subgroup analysis, the overall effect was significantly effective in reducing TC, LDL levels and improving HDL levels in CV risk patients.
Our study findings provide consistent evidence that intake of garlic reduces CVD risk factors.
4Total cholesterol reductionMeta-AnalysisCited 37×n=26 · very small study2012
Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
Zeng T et al. · Journal of the science of food and agriculture (2012)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Garlic could reduce serum TC and TG levels, and garlic therapy should benefit patients with risk of cardiovascular diseases.
This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
De Greef D et al. · Seminars in cancer biology (2021)
This investigation employs criteria for systematic review and critically analyzes published in vitro, in vivo and clinical studies.
Concerns and limitations that have arisen in past studies regarding standards of measurement, bioavailability, and method of delivery are addressed.
Overall, it is hoped that through this systematic and comprehensive review, future researchers can be acquainted with the updated data assembled on anticancer properties of garlic and its phytoconstituents.
Some nutraceuticals might have a positive impact on BP in humans.
Borghi C et al. · British journal of clinical pharmacology (2017)
Some nutraceuticals might have a positive impact on BP in humans.
Further clinical research is needed, to identify from the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for widespread and long-term use in the general population with a low-added cardiovascular risk related to uncomplicated hypertension.
7C-reactive protein levelsMeta-AnalysisCited 13×n=17 · very small study2020
This meta-analysis showed that supplementation with garlic could reduce the level of circulating CRP and AGE could reduce the level of TNF-α and CRP, whereas it had no significant effect on the IL-6 level.
Mirzavandi F et al. · Diabetes & metabolic syndrome (2020)
Borderline
Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05).
9Colorectal cancer riskSystematic ReviewCited 57×2007
On balance, there is consistent scientific evidence derived from RCT of animal studies reporting protective effects of garlic on CRC despite great heterogeneity of measures of intakes among human epidemiological studies.
Ngo SN et al. · The Journal of nutrition (2007)
Large benefit
← WorseNo effectBetter →
One randomized controlled trial (RCT, level II) reported a statistically significant 29% reduction in both size and number of colon adenomas in CRC patients taking aged garlic extract.
A published meta-analysis (level III) of 7 of these studies confirmed this inverse association, with a 30% reduction in relative risk.
Five of 8 case control/cohort studies (level III) suggested a protective effect of high intake of raw/cooked garlic and 2 of 8 of these studies suggested a protective effect for distal colon.
10Coronary artery calcification progressionRCTCited 33×n=104 · medium study2020
AGE inhibits CAC progression, lowers IL-6, glucose levels and blood pressure in patients at increased risk of cardiovascular events in a European cohort.
Wlosinska M et al. · BMC complementary medicine and therapies (2020)
Huge harm
← WorseNo effectBetter →
Borderline
There was a significant (p < 0.05) change in CAC progression (OR: 2.95 [1.05-8.27]), blood glucose (OR: 3.1 [1.09-8.85]) and IL-6 (OR 2.56 [1.00-6.53]) in favor of the active group.
The AGE Algorithm, at a selected probability cut-off value of 0.5, the accuracy score for CAC progression was 80%, precision score of 79% and recall score 83%.
The score for blood pressure was 74% (accuracy, precision and recall).
Wlosinska M et al. · International wound journal (2019)
Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry.
A repeated measures analysis of variance (ANOVA) with a Greenhouse-Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points.
Increased microcirculation could hypothetically facilitate wound healing.
12Diastolic blood pressure reductionCrossoverCited 23×n=67 · small study2022
The potential beneficial effects of ABG may contribute to obtaining an optimal DBP.
Valls RM et al. · Nutrients (2022)
Noticeable benefit
← WorseNo effectBetter →
At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg.
Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention.
The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia.
It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment.
Serrano JCE et al. · Nutrients (2023)
Noticeable benefit
← WorseNo effectBetter →
A reduction in systolic and diastolic blood pressure of 1.8 mmHg (0.7 to 4.1 95% CI) and 1.5 mmHg (0.3 to 3.0 95% CI), respectively, was observed.
It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment.
No changes in endothelial function and inflammatory cytokines were observed.
14Gingival inflammation and bleeding reductionRCTCited 17×n=134 · medium study2018
This research demonstrated that daily consumption of AGE benefits oral health by reducing gingival inflammation and gingival bleeding, as compared to a placebo control.
Zini A et al. · The Journal of clinical dentistry (2018)
Likely real
One hundred and fifty-one participants followed the inclusion criteria; 50.3% males, with an average age of 32.7 ± 8.2 years.
Only 134 subjects completed the four-month study (11.3% attrition rate).
A statistically significant decrease of the Modified Gingival Index and Gingival Bleeding Index scores was shown for the AGE compared to the placebo group, both between and within groups (p < 0.001).
15Cold and flu severity reductionRCTCited 59×n=120 · medium study2016
This trial was registered at clinicaltrials.gov as NCT01390116.
Percival SS · The Journal of nutrition (2016)
After 90 d, although the number of illnesses was not significantly different, the AGE group showed reduced cold and flu severity, with a reduction in the number of symptoms, the number of days participants functioned suboptimally, and the number of work/school days missed.
These results suggest that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported.
The results also suggest that the immune system functions well with AGE supplementation, perhaps with less accompanying inflammation.
16Inflammation and immunity markersRCTCited 73×n=51 · small study2018
Six weeks of AGE consumption modulated immune cell distribution, prevented the increase of serum TNF-α and IL-6 concentrations and reduced blood LDL concentration in adults with obesity.
Xu C et al. · Clinical nutrition ESPEN (2018)
There was no difference in percentage of NK cells between the two groups.
Six weeks of AGE consumption modulated immune cell distribution, prevented the increase of serum TNF-α and IL-6 concentrations and reduced blood LDL concentration in adults with obesity.
AGE, taken consistently, may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation in adults with obesity.
17Endothelial functionRCTCited 71×n=26 · very small study2016
In this group of type 2 diabetic patients at high cardiovascular risk, 4 weeks treatment with AGE did not significantly improve endothelial function, vascular inflammation, oxidative stress or insulin resistance.
Atkin M et al. · Journal of diabetes and its complications (2016)
Of the 26 patients studied (male 17, female 9), age was 61 ± 8 years (mean ± 1 SD), HbA1c 7.2 ± 1.1%, BP 130/75 ± 15.9/9.8 mmHg, total cholesterol 4.2 ± 0.81 mmol/l, triglyceride 2.11 ± 1.51 mmol/l, and HDL cholesterol 1.04 ± 0.29 mmol/l.
The majority of patients were being treated with metformin (59%), aspirin (50%) and statin (96%) therapy. 36% were treated with an ACEI.
In this group of type 2 diabetic patients at high cardiovascular risk, 4 weeks treatment with AGE did not significantly improve endothelial function, vascular inflammation, oxidative stress or insulin resistance.
18Low attenuation plaque percentageRCTCited 57×n=27 · very small study2016
This study indicates that the %LAP change was significantly greater in the AGE group than in the placebo group.
Matsumoto S et al. · The Journal of nutrition (2016)
Noticeable benefit
← WorseNo effectBetter →
Likely real
The %LAP change was significantly reduced in the AGE group compared with the placebo group (-1.5% ± 2.3% compared with 0.2% ± 2.0%, P = 0.0049).
In contrast, no difference was observed in %TPV change (0.3% ± 3.3% compared with 1.6% ± 3.0%, P = 0.13), %NCP change (0.2% ± 3.3% compared with 1.4% ± 2.9%, P = 0.14), and %DC change (0.2% ± 1.4%, compared with 0.2% ± 1.7%, P = 0.99).
Multivariable linear regression analysis found a beneficial effect of AGE on %LAP regression (β: -1.61; 95% CI: -2.79, -0.43; P = 0.008).
19Plasma adiponectin levelsCrossoverCited 48×n=46 · small study2013
The present results have shown for the first time that the administration of AGE for 12 weeks increased plasma adiponectin levels in patients with MS.
Gómez-Arbeláez D et al. · Mediators of inflammation (2013)
Likely real
The administration of AGE increased the plasma levels of adiponectin (P = 0.027).
The present results have shown for the first time that the administration of AGE for 12 weeks increased plasma adiponectin levels in patients with MS.
This suggests that AGE might be a useful, novel, nonpharmacological therapeutic intervention to increase adiponectin and to prevent cardiovascular (CV) complications in individuals with MS.