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Head-to-head evidence comparison — which supplement is right for you?
Aloe Vera vs Iron: Iron has the stronger overall evidence (9 vs 5.6/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Iron wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
6 of 8 studies with measurable effects showed benefit.
Top outcomes
Topical: apply gel as needed. Oral: ~50-100mg inner-leaf extract or ~30-50ml decolorized juice daily. The oral amounts are typical label doses. The one oral trial used 10 ml a day of aloe syrup.
Any time of day
Topical inner-leaf gel; decolorized inner-leaf for oral use
18-40mg elemental iron for deficiency (varies by severity) (a typical label dose, not the dose used in the cited trials, which used 60 to 120 mg a day)
On empty stomach if tolerated, Away from tea, coffee, dairy
Ferrous bisglycinate (gentle, well-absorbed) or iron protein succinylate
and 6 more not shown
1-4 weeks
2-4 weeks
Hours
2-4 weeks
4-8 weeks
4-12 weeks
Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review.
Advances in skin & wound care (2022) · Meta analysis · n=133
Systematic review of randomised trials of topical aloe vera in wound care (28 included), with a meta-analysis of the 4 second-degree burn trials: 133 patients, 163 wounds
Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan (2015) · Rct · n=79
Pilot trial: 79 people with reflux were randomised to aloe vera syrup 10 mL/day, omeprazole or ranitidine for 4 weeks
The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial.
Current drug discovery technologies (2024) · Rct · n=66
Double-blind randomised trial in 66 patients with diabetic foot ulcers: saline wash and sterile gauze in both groups, with a thin layer of aloe vera gel under the dressing in the intervention group
Daily oral iron supplementation during pregnancy
The Cochrane database of systematic reviews (2024) · Meta analysis · n=48971
There is probably little to no difference in maternal death (2 versus 4 events, RR 0.57, 95% CI 0.12 to 2.69; 3 trials, 14,060 women; moderate-certainty evidence).
The Prevalence of Anemia among Pregnant Women in China: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=1376204
The results showed that the prevalence of anemia, ID, and IDA among pregnant women in China were 30.7% (95% CI: 26.6%, 34.7%), 45.6% (95% CI: 37.0%, 54.2%), and 17.3% (95% CI: 13.9%, 20.7%), respectively.
Treatment for women with postpartum iron deficiency anaemia
The Cochrane database of systematic reviews (2024) · Meta analysis · n=4558
Intravenous iron versus oral iron supplementation The evidence is very uncertain about the effect of intravenous iron on mortality (risk ratio (RR) 2.95, 95% confidence interval (CI) 0.12 to 71.96; P = 0.51; I² = not applicable; 3 RCTs; 1 event; 572 women; very low-certainty evidence).
Iron has a higher evidence score (9/10 vs 5.6/10) and wins in 2 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.