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Head-to-head evidence comparison — which supplement is right for you?
Resistant Starch wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
4 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
17 of 19 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Andrographis and Resistant Starch have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
15-30g daily
With meals, Divide throughout day for higher doses
Raw potato starch (unmodified) or green banana flour
2-5 days
2-5 days
2-5 days
2-4 weeks
4-8 weeks
1-2 weeks
First 1-2 weeks
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Metabolic Effects of Resistant Starch Type 2: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2019) · Meta analysis · n=670
However, these outcomes were heavily influenced by positive results from a small number of individual studies which contradicted the conclusions of the majority of trials.
Acute Effects of Dietary Fiber in Starchy Foods on Glycemic and Insulinemic Responses: A Systematic Review of Randomized Controlled Crossover Trials
Nutrients (2023) · Systematic review
Data on insoluble DF and glucose metabolism are scarce.
The Effects of Resistant Starch on Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis
Nutrition and cancer (2022) · Meta analysis · n=739
We used from the effect size, as estimated by the standardized mean difference (SMD) with 95% confidence intervals (95%CI) to perform the random method meta-analysis, with P value ≦0.05 as statistically significant.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Meta-analysis showed modest 3.32 mg/dL reduction in fasting glucose. Effects were heavily influenced by small number of positive studies, with majority showing mixed results. Higher doses increase GI side effects.
AI-estimated from published studies. Interpret as directional guidance.
Resistant Starch has a higher evidence score (9/10 vs 8.5/10) and wins in 3 of 3 categories.
For reduce inflammation, Resistant Starch has a higher relevance score (85 vs 70).
No known interactions between Andrographis and Resistant Starch have been documented in our database. However, always consult a healthcare provider before combining supplements.