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Andrographis paniculata
Studied for comfort and symptom duration during upper-respiratory infections when taken at onset — also supports liver health.
What the evidence says
Andrographis appears to help in 3 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2002–2026 with a typical study size of 139 participants.
Based on 45 studies · 4 meta-analyses · 17 RCTs · 9,999 total participants
Confidence
High confidenceWhat the studies found
By outcome
Multiple RCTs and a large meta-analysis show andrographis reduces cough and sore-throat severity in respiratory infections, with good safety, though benefits are short-term and it failed in COVID and ulcerative colitis.
No trials currently enrolling · 13 completed on ClinicalTrials.gov
2 of the completed trials have posted results
Registered trials show research momentum for Andrographis, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Andrographis, known as 'King of Bitters' in Ayurveda, is used for immune support and respiratory infections. Clinical trials show it can significantly reduce the severity and duration of upper respiratory infections when taken at first sign of symptoms. Also used for digestive issues and liver support.
Enhances immune cell activity
Reduces inflammatory response
Direct antiviral effects
How Andrographis works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Avoid — may have anti-fertility effects
Avoid — may stimulate immune system
May increase bleeding risk
May lower blood pressure
May counteract immunosuppression
Tip: Take with food; very bitter
Tip: Usually resolves
Tip: May be part of immune response
Tip: Discontinue if rash occurs
Andrographis has an evidence score of 7/10 — strong evidence based on 45 indexed studies, including 3 meta-analyses. Studied for comfort and symptom duration during upper-respiratory infections when taken at onset — also supports liver health. Representative study: PMID 33372366.
The commonly studied dose of Andrographis is 400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Andrographis is with meals. Take it with food. Andrographolides are mildly lipophilic and can cause GI discomfort on an empty stomach.
Andrographis has a safety rating of "moderate". That is a category, not a measure of individual risk, and there are precautions worth knowing. The most commonly reported side effects are GI upset, headache, fatigue. Use caution if any of these apply to you: Pregnancy (may have anti-fertility effects); Autoimmune conditions (may stimulate immune system).
Aged Garlic Extract
Likely helpsOdorless garlic extract with evidence for blood pressure and cardiovascular markers, and one trial reporting milder colds and flu.
Curcumin
Probably helpsTurmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.
Ginger Extract
Likely helpsGingerols and shogaols reduce nausea, accelerate gastric emptying, and provide systemic anti-inflammatory benefits.
Chlorella
Too few graded studiesFreshwater algae with the highest chlorophyll content of any plant — binds heavy metals and supports detoxification pathways.
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Reviewed by Dr. Baher Al Hakim · Last reviewed May 2026 · evidence from 45 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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