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Andrographis paniculata
Clinically shown to reduce upper respiratory infection severity and duration when taken at first symptoms — also supports liver health.
What the evidence says
Andrographis helped in about half (4/7) of the studies that measured an effect — promising, but not unanimous.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2026 with a typical study size of 103 participants.
Based on 29 studies · 3 meta-analyses · 14 RCTs · 7,487 total participants
Confidence
HighWhat the studies found
By outcome
Andrographis has an evidence score of 8.5/10 — very strong evidence based on 29 indexed studies, including 3 meta-analyses. Clinically shown to reduce upper respiratory infection severity and duration when taken at first symptoms — also supports liver health.
The commonly studied dose of Andrographis is 400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use. Research points to an estimated optimal dose around 400mg, with a minimum effective dose near 200mg. Individual response varies — start low and adjust.
The best time to take Andrographis is with meals. Take it with food. Andrographolides are mildly lipophilic and can cause GI discomfort on an empty stomach.
Aged Garlic Extract
Likely helpsOdorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
Spirulina
Likely helpsBlue-green algae with 60-70% complete protein and unique phycocyanin antioxidant — lowers cholesterol, blood pressure, and blood sugar.
Last reviewed May 2026 · evidence from 32 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Andrographis, known as 'King of Bitters' in Ayurveda, is one of the most well-researched herbs for immune support and respiratory infections. Clinical trials show it can significantly reduce the severity and duration of upper respiratory infections when taken at first sign of symptoms. Also used for digestive issues and liver support.
Enhances immune cell activity
Reduces inflammatory response
Direct antiviral effects
How Andrographis works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
Loading: For acute infections: high dose (400mg 3x daily) for first 3-5 days
Take with food
| Form | Type |
|---|---|
| 💊Standardized extract (10-30% andrographolides) | Recommended |
| 💊Kan Jang (fixed combination) | Alternative |
| 💊SHA-10 extract | Alternative |
Kan Jang and SHA-10 are specific extracts used in clinical trials. Very bitter raw.
Minimum: 3 days
Optimal: 5 days
Cycling: Use for acute illness (3-10 days). Not intended for long-term daily use.
Note: Most effective when started at first sign of illness. Continue for 3-5 days.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Less severe symptoms
Shorter illness duration
Less sore throat, fatigue, runny nose
Avoid — may have anti-fertility effects
Avoid — may stimulate immune system
May increase bleeding risk
May lower blood pressure
May counteract immunosuppression
Tip: Take with food; very bitter
Tip: Usually resolves
Tip: May be part of immune response
Tip: Discontinue if rash occurs
Andrographis is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are GI upset, headache, fatigue. Use caution if any of these apply to you: Pregnancy (may have anti-fertility effects); Autoimmune conditions (may stimulate immune system).
Olive Leaf Extract
Likely helpsOleuropein-rich extract with antiviral, antibacterial, and blood pressure-lowering effects — part of the Mediterranean diet's protective profile.
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