Andrographis paniculata
Clinically shown to reduce upper respiratory infection severity and duration when taken at first symptoms — also supports liver health.
Andrographis, known as 'King of Bitters' in Ayurveda, is one of the most well-researched herbs for immune support and respiratory infections. Clinical trials show it can significantly reduce the severity and duration of upper respiratory infections when taken at first sign of symptoms. Also used for digestive issues and liver support.
Enhances immune cell activity
Reduces inflammatory response
Direct antiviral effects
How Andrographis works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
Loading: For acute infections: high dose (400mg 3x daily) for first 3-5 days
Take with food
| Form | Type |
|---|---|
| 💊Standardized extract (10-30% andrographolides) | Recommended |
| 💊Kan Jang (fixed combination) | Alternative |
| 💊SHA-10 extract | Alternative |
Kan Jang and SHA-10 are specific extracts used in clinical trials. Very bitter raw.
Minimum: 3 days
Optimal: 5 days
Cycling: Use for acute illness (3-10 days). Not intended for long-term daily use.
Note: Most effective when started at first sign of illness. Continue for 3-5 days.
Less severe symptoms
Shorter illness duration
Less sore throat, fatigue, runny nose
Avoid — may have anti-fertility effects
Avoid — may stimulate immune system
May increase bleeding risk
May lower blood pressure
May counteract immunosuppression
Tip: Take with food; very bitter
Tip: Usually resolves
Tip: May be part of immune response
Tip: Discontinue if rash occurs
Top studies from 32+ peer-reviewed papers
Iyengar P et al. • Nutrients (2024)
“Research with larger scale and well-designed RCTs, manufacturing regulations, and education are needed.”
Worakunphanich W et al. • Pharmacoepidemiology and drug safety (2021)
“Like other medicine, Andrographis paniculata can cause some AEs.”
Hancke JL et al. • Phytotherapy research : PTR (2019)
“Overall, it can be concluded that ParActin® in 300 and 600 mg/day dosages were found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.”
Dafur GS et al. • Journal of microbiology and biotechnology (2024)
“This review highlights the need for further research on andrographolide's antifungal activity, mechanisms of action, clinical safety, toxicity, and potential applications in antimicrobial resistance strategies.”
Anis Amiera MA et al. • PeerJ (2024)
“These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.”
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