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Head-to-head evidence comparison — which supplement is right for you?
Vitamin B6 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
4 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
9 of 11 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Andrographis and Vitamin B6 have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
25-100mg daily
Morning with food, Can take with other B vitamins
P-5-P (Pyridoxal-5-Phosphate)
2-5 days
2-5 days
2-5 days
2-4 weeks
1-2 cycles
Months of high doses
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
The Cochrane database of systematic reviews (2018) · Meta analysis · n=83000
We found that giving B vitamin supplements to cognitively healthy adults, mainly in their 60s and 70s, probably has little or no effect on global cognitive function at any time point up to 5 years (SMD values from -0.03 to 0.06) and may also have no effect at 5-10 years (SMD -0.01).
Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis
JAMA network open (2024) · Meta analysis · n=492
No association between effect sizes and psychotic severity was found.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Based on systematic review of nutritional interventions for PMS psychological symptoms. Evidence quality limited by study heterogeneity and need for more consistent protocols.
AI-estimated from published studies. Interpret as directional guidance.
Vitamin B6 has a higher evidence score (9/10 vs 8.5/10) and wins in 3 of 3 categories.
For support immune system, Andrographis has a higher relevance score (90 vs 65).
No known interactions between Andrographis and Vitamin B6 have been documented in our database. However, always consult a healthcare provider before combining supplements.