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Head-to-head evidence comparison — which supplement is right for you?
Arginine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
11 of 19 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
7 of 7 studies with measurable effects showed benefit.
Top outcomes
3-6g daily
30-60 minutes before exercise, Divided doses throughout the day for cardiovascular benefits
L-Arginine powder or capsules
1000-3000mg
Morning or pre-workout
Cordyceps militaris extract (fruiting body)
30-60 minutes
During exercise
2-4 weeks
Immediate
1-4 weeks
2-4 weeks
Nutritional interventions for preventing and treating pressure ulcers
The Cochrane database of systematic reviews (2024) · Meta analysis · n=7920
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
Nutrients (2023) · Meta analysis · n=2841
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
Nutritional interventions for treating foot ulcers in people with diabetes
The Cochrane database of systematic reviews (2020) · Meta analysis · n=629
It is also uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases the proportion of ulcers healed at 16 weeks compared with placebo (RR 1.09, 95% CI 0.85 to 1.40).
Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease
The Cochrane database of systematic reviews (2014) · Meta analysis · n=1746
We found that Cordyceps preparation, as an adjuvant therapy to conventional medicine, showed potential promise to decrease serum creatinine, increase creatine clearance, reduce proteinuria and alleviate CKD-associated complications, such as increased haemoglobin and serum albumin.
Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials
Journal of ethnopharmacology (2024) · Meta analysis · n=928
Compared with conventional treatment, adjuvant treatment with CS of lung cancer not only improve TRR, QOL and immune function, but also reduce the incidence of ADRs and radiation pneumonitis.
Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan (2019) · Meta analysis · n=655
However, there was no significant improvement for serum creatinine and low-density lipoprotein cholesterol.
Based on meta-analysis showing mean reductions of 5.39 mmHg systolic and 2.66 mmHg diastolic. Effects are modest and may not be clinically significant for all individuals. GI side effects increase notably above 6g.
Based on multiple meta-analyses showing improvements in serum creatinine, creatinine clearance, and proteinuria in kidney disease patients. Effects were modest and primarily as adjuvant therapy. Study quality was noted as unclear in several reviews.
AI-estimated from published studies. Interpret as directional guidance.
Arginine has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For athletic performance, Cordyceps has a higher relevance score (70 vs 65).
No known interactions between Arginine and Cordyceps have been documented in our database. However, always consult a healthcare provider before combining supplements.