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Head-to-head evidence comparison — which supplement is right for you?
Arginine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
14 of 22 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
3-6g daily
30-60 minutes before exercise, Divided doses throughout the day for cardiovascular benefits
L-Arginine powder or capsules
15-45g dried berries daily, or ~150-300mg standardized Lycium barbarum polysaccharide (LBP) extract
any
Dried berries or standardized LBP extract
30-60 minutes
During exercise
2-4 weeks
Immediate
8-12 weeks
4-12 weeks
8-12 weeks
Nutritional interventions for preventing and treating pressure ulcers
The Cochrane database of systematic reviews (2024) · Meta analysis · n=7920
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
Nutrients (2023) · Meta analysis · n=2841
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
Nutritional interventions for treating foot ulcers in people with diabetes
The Cochrane database of systematic reviews (2020) · Meta analysis · n=629
It is also uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases the proportion of ulcers healed at 16 weeks compared with placebo (RR 1.09, 95% CI 0.85 to 1.40).
Cardiovascular disease risk reduction with wolfberry consumption: a systematic review and meta-analysis of randomized controlled trials.
European journal of nutrition (2022) · Meta analysis
Improved cardiovascular risk markers
L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs.
Medicine (2023) · Meta analysis
Improvements in lipid markers
A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum.
Journal of medicinal food (2012) · Meta analysis
Improved subjective well-being/energy
Based on meta-analysis showing mean reductions of 5.39 mmHg systolic and 2.66 mmHg diastolic. Effects are modest and may not be clinically significant for all individuals. GI side effects increase notably above 6g.
AI-estimated from published studies. Interpret as directional guidance.
Arginine has a higher evidence score (9/10 vs 5.2/10) and wins in 2 of 3 categories.
For support heart health, Arginine has a higher relevance score (62 vs 50).
No known interactions between Arginine and Goji Berries have been documented in our database. However, always consult a healthcare provider before combining supplements.