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Head-to-head evidence comparison — which supplement is right for you?
Ornithine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
300-600mg daily (standardized extract)
Morning for daytime stress, Evening for sleep support
KSM-66 or Sensoril standardized extract
2-6g daily
Before exercise for fatigue reduction, Before bed for sleep support
L-Ornithine HCl
2-4 weeks
2-4 weeks
2-4 weeks
First week
During prolonged exercise
Hours post-exercise
1-2 weeks
Immediate
Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis
Journal of the American Nutrition Association (2024) · Meta analysis · n=873
Significant reduction in HAM-A anxiety scores (p=0.0007)
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
Nutrients (2024) · Rct · n=131
Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis.
Plant-derived nootropics and human cognition: A systematic review
Critical reviews in food science and nutrition (2023) · Systematic review
Bacopa monnieri improves language, learning and memory.
Comparative Efficacy of Treatment Options for Minimal Hepatic Encephalopathy: A Systematic Review and Network Meta-Analysis
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2020) · Meta analysis · n=1563
In a meta-analysis of data from 25 trials, we found rifaximin and lactulose to be most effective for reversal of minimal HE in patients with cirrhosis.
Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review
Amino acids (2025) · Systematic review
The main observed adverse events were gastrointestinal disorders.
Efficacy of L-ornithine L-aspartate for minimal hepatic encephalopathy in patients with cirrhosis: A meta-analysis of randomized controlled trials
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology (2024) · Meta analysis · n=292
LOLA has significant beneficial effects on reversal of MHE and prevention of OHE in patients with cirrhosis compared with placebo or no intervention.
Based on meta-analysis showing significant HAM-A score reduction (p=0.0007) and RCT evidence at 125mg dose. High heterogeneity (I2=98%) in pooled analysis suggests variable response. Extract standardization affects bioavailability.
Evidence specific to L-ornithine L-aspartate form in cirrhosis patients. Meta-analysis of 292 patients showed significant benefit vs placebo. GI adverse events noted as main side effect. Limited applicability to healthy populations.
AI-estimated from published studies. Interpret as directional guidance.
Ornithine has a higher evidence score (8.5/10 vs 7.5/10) and wins in 2 of 3 categories.
For improve deep sleep quality, Ashwagandha has a higher relevance score (75 vs 55).
No known interactions between Ashwagandha and Ornithine have been documented in our database. However, always consult a healthcare provider before combining supplements.