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Head-to-head evidence comparison — which supplement is right for you?
Apigenin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Apigenin and Ashwagandha have evidence — compare verdict strength side-by-side.
50mg before bed
30-60 minutes before bed
Apigenin extract capsules
300-600mg daily (standardized extract)
Morning for daytime stress, Evening for sleep support
KSM-66 or Sensoril standardized extract
30-60 minutes
30-60 minutes
N/A
2-4 weeks
2-4 weeks
2-4 weeks
First week
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Renal failure (2025) · Meta analysis · n=1443
Meanwhile, when the treatment duration exceeds 12 weeks, AS demonstrated a significant reduction in fasting blood glucose levels, indicating a time-dependent effect.
Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives
CNS neuroscience & therapeutics (2025) · Systematic review
Although levodopa is indispensable for the symptomatic management of PD, emerging evidence supports the integration of plant-derived bioactive compounds as adjunct therapies with disease-modifying potential.
Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
Nutrients (2018) · Meta analysis · n=12
High intake of dietary flavonols, flavones and anthocyanidins may decrease the risk of colorectal cancer; the pooled odds ratio (OR) for the highest intake compared with the lowest was 0.70 (0.54⁻0.90), 0.79 (0.83⁻0.99) and 0.78 (0.64⁻0.95), respectively.
Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis
Journal of the American Nutrition Association (2024) · Meta analysis · n=873
Significant reduction in HAM-A anxiety scores (p=0.0007)
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
Nutrients (2024) · Rct · n=131
Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis.
Plant-derived nootropics and human cognition: A systematic review
Critical reviews in food science and nutrition (2023) · Systematic review
Bacopa monnieri improves language, learning and memory.
Based on preclinical studies showing neuroinflammation inhibition and lung injury models. Human clinical data lacking. Effects may vary significantly based on bioavailability and individual response.
Based on meta-analysis showing significant HAM-A score reduction (p=0.0007) and RCT evidence at 125mg dose. High heterogeneity (I2=98%) in pooled analysis suggests variable response. Extract standardization affects bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Apigenin has a higher evidence score (8/10 vs 7.5/10) and wins in 2 of 3 categories.
For reduce anxiety & stress, Ashwagandha has a higher relevance score (95 vs 70).
No known interactions between Apigenin and Ashwagandha have been documented in our database. However, always consult a healthcare provider before combining supplements.