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Head-to-head evidence comparison — which supplement is right for you?
B-Complex wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both B-Complex and Lion's Mane have evidence — compare verdict strength side-by-side.
1 capsule daily (per label)
Morning with breakfast
Methylated B-complex (methylcobalamin, methylfolate)
500-3000mg daily
Morning with breakfast
Fruiting body extract (1:1 or higher)
2-4 weeks
4-8 weeks
Immediate
4-8 weeks
4 weeks
4-8 weeks
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2024) · Meta analysis · n=42768
The meta-analysis on the effects of folate-based B vitamin supplementation on cognitive function showed a significant overall impact (Z = 3.84; p = 0.0001; SMD, 0.18; 95% CI, 0.09, 0.28).
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals
Nutrients (2019) · Meta analysis · n=2015
Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03).
Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review
Medical sciences (Basel, Switzerland) (2026) · Systematic review
Results: These mushroom-derived treatments enhanced the migration of Schwann cells mainly via the FGF-2 signalling and MAPK pathway.
Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review
Nutrients (2025) · Systematic review
Advances in biotechnological methods, including optimized cultivation techniques and novel extraction methods, may further enhance the bioavailability and pharmacological effects of H. erinaceus.
Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential
International journal of molecular sciences (2025) · Systematic review
Therefore, there is a strong demand for innovative, affordable, and minimally invasive treatments such as medicinal mushrooms.
Multiple meta-analyses show small but statistically significant benefits for cognitive function in older adults and stroke prevention populations. Effect sizes are modest (SMD ~0.15-0.18). Benefits may be more pronounced in B-vitamin deficient populations.
Based on limited RCT data showing improved Stroop task performance in young adults and cognitive function in older adults. Effects are gradual and develop over weeks. Bioavailability varies significantly between forms (fruiting body > dual extract > mycelium on grain).
AI-estimated from published studies. Interpret as directional guidance.
B-Complex has a higher evidence score (9/10 vs 7/10) and wins in 2 of 3 categories.
For improve memory & learning, Lion's Mane has a higher relevance score (80 vs 55).
No known interactions between B-Complex and Lion's Mane have been documented in our database. However, always consult a healthcare provider before combining supplements.