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Head-to-head evidence comparison — which supplement is right for you?
B. coagulans vs L. reuteri DSM 17938: they're closely matched on evidence (5 vs 6/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B. coagulans and L. reuteri DSM 17938 are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both B. coagulans and L. reuteri DSM 17938 have evidence — compare verdict strength side-by-side.
1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.
any
Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims
1 x 10^8 CFU daily (5 drops) for infant colic — the dose used in every positive trial
any
Oil-suspension drops standardized to DSM 17938
4-12 weeks
4 weeks
n/a
n/a
1-3 weeks
n/a
1-3 days
4 weeks
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Nutrients (2023) · Meta analysis
B. coagulans MTCC 5856 (SUCRA 96.9%) and B. coagulans Unique IS2 (SUCRA 92.6%) were among the most effective probiotics for improving abdominal pain
Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr (2022) · Meta analysis
Probiotics increased stool frequency overall (SMD 0.71, 95% CI 0.37-1.04, P<0.00001), with Bifidobacterium lactis driving the effect
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore) (2023) · Rct · n=70
GSRS indigestion score fell from 8.91 to 3.06 in the probiotic group versus 9.42 to 8.43 on placebo; between-group P<0.001
Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis.
Pediatrics (2018) · Meta analysis
Day-21 adjusted mean difference in cry/fuss time: -25.4 min/day (95% CI -47.3 to -3.5)
Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial.
BMJ (2014) · Rct · n=167
Probiotic group cried/fussed 49 minutes MORE than placebo at 1 month (95% CI 8 to 90, P=0.02)
Probiotics to prevent infantile colic.
Cochrane Database Syst Rev (2019) · Meta analysis
No difference in new cases of colic: RR 0.46 (95% CI 0.18-1.19), low certainty
Both B. coagulans and L. reuteri DSM 17938 are closely matched — the best choice depends on your specific health goals.
For improve digestion, B. coagulans has a higher relevance score (58 vs 55).
No known interactions between B. coagulans and L. reuteri DSM 17938 have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.