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Head-to-head evidence comparison — which supplement is right for you?
B. coagulans vs L. reuteri DSM 17938: L. reuteri DSM 17938 has the stronger overall evidence (6 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
L. reuteri DSM 17938 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both B. coagulans and L. reuteri DSM 17938 have evidence — compare verdict strength side-by-side.
1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.
Any time of day
Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims
1 x 10^8 CFU daily (5 drops) for infant colic — the dose used in every positive trial
Any time of day
Oil-suspension drops standardized to DSM 17938
4-12 weeks
4 weeks
n/a
n/a
1-3 weeks
n/a
1-3 days
4 weeks
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Nutrients (2023) · Meta analysis
B. coagulans MTCC 5856 (SUCRA 96.9%) and B. coagulans Unique IS2 (SUCRA 92.6%) were among the most effective probiotics for improving abdominal pain
Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr (2022) · Meta analysis
Probiotics increased stool frequency overall (SMD 0.71, 95% CI 0.37-1.04, P<0.00001), with Bifidobacterium lactis driving the effect
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore) (2023) · Rct · n=70
GSRS indigestion score fell from 8.91 to 3.06 in the probiotic group versus 9.42 to 8.43 on placebo; between-group P<0.001
Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis.
Pediatrics (2018) · Meta analysis
Day-21 adjusted mean difference in cry/fuss time: -25.4 min/day (95% CI -47.3 to -3.5)
Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial.
BMJ (2014) · Rct · n=167
Probiotic group cried/fussed 49 minutes MORE than placebo at 1 month (95% CI 8 to 90, P=0.02)
Probiotics to prevent infantile colic.
Cochrane Database Syst Rev (2019) · Meta analysis
No difference in new cases of colic: RR 0.46 (95% CI 0.18-1.19), low certainty
L. reuteri DSM 17938 has a higher evidence score (6/10 vs 5/10) and wins in 2 of 3 categories.
For improve digestion, B. coagulans has a higher relevance score (58 vs 55).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.