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Head-to-head evidence comparison — which supplement is right for you?
Canagliflozin vs Pioglitazone (Actos): Canagliflozin has the stronger overall evidence (4.5 vs 4/10); they're alternatives for support heart health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Canagliflozin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Canagliflozin and Pioglitazone (Actos) have evidence — compare verdict strength side-by-side.
Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.
morning
Oral tablet (canagliflozin)
Off-label metabolic use mirrors diabetes dosing (e.g. 15–45 mg once daily) under a clinician. A prescription drug; not an approved longevity regimen.
morning
Oral tablet (pioglitazone)
Unknown in humans
Months to years
Weeks to months
Throughout use
Weeks to months
Months to years
Months
Throughout use
Canagliflozin extends life span in genetically heterogeneous male but not female mice.
JCI insight (2020) · Animal
NIA Interventions Testing Program: canagliflozin extended lifespan in male mice
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.
The New England journal of medicine (2015) · Rct · n=7020
EMPA-REG OUTCOME randomized trial (empagliflozin, same class)
Empagliflozin in Heart Failure with a Preserved Ejection Fraction.
The New England journal of medicine (2021) · Rct
EMPEROR-Preserved randomized trial (empagliflozin)
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack.
The New England journal of medicine (2016) · Rct · n=3876
IRIS randomized trial in patients with insulin resistance but no diabetes after recent stroke/TIA (n=3,876)
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial.
Lancet (London, England) (2005) · Rct · n=5238
PROactive randomized trial in high-cardiovascular-risk type 2 diabetics (n=5,238)
Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial.
Annals of internal medicine (2016) · Rct
Randomized, placebo-controlled trial of long-term pioglitazone in NASH with prediabetes/type 2 diabetes
Canagliflozin has a higher evidence score (4.5/10 vs 4/10) and wins in 2 of 3 categories.
For support heart health, Canagliflozin has a higher relevance score (70 vs 55).
No known interactions between Canagliflozin and Pioglitazone (Actos) have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.