Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Probiotics wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
30 of 39 studies with measurable effects showed benefit.
Top outcomes
OTC wellness: 10-50mg/day (some anxiety studies used higher acute doses ~300mg); take with a fat-containing meal (increases absorption several-fold). Prescription Epidiolex for epilepsy is dosed by body weight under medical supervision.
with-meals, evening
CBD oil/tincture (third-party tested for potency and purity)
10-20 billion CFU
With or without food (strain-dependent), Same time daily for consistency
Capsules with multiple strains
Acute-4 weeks
1-8 weeks
Weeks
Acute
2-4 weeks
4-8 weeks
4-8 weeks
First 1-2 weeks
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.
The New England journal of medicine (2017) · Rct · n=120
Convulsive seizures fell from 12.4 to 5.9/month with CBD vs 14.9 to 14.1 with placebo
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.
Lancet (London, England) (2018) · Rct
Significant reduction in drop-seizure frequency vs placebo
Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.
The New England journal of medicine (2018) · Rct
Fewer drop seizures vs placebo
Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2022) · Meta analysis · n=708
Three trials using Lactobacilli-based probiotics reported that the incidence of oral mucositis in the probiotic group was significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] = 0.77−0.93, p = 0.0004).
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
The Cochrane database of systematic reviews (2017) · Meta analysis · n=9955
A complete case analysis (i.e. participants who completed the study) among trials investigating CDAD (31 trials, 8672 participants) suggests that probiotics reduce the risk of CDAD by 60%.
Based on meta-analyses showing benefits for IBS and digestive symptoms. Effect sizes varied considerably between studies with low to very low certainty of evidence. Initial GI symptoms common when starting but typically resolve within 1-2 weeks.
AI-estimated from published studies. Interpret as directional guidance.
Probiotics has a higher evidence score (9/10 vs 5.8/10) and wins in 3 of 3 categories.
For reduce inflammation, Probiotics has a higher relevance score (95 vs 42).
No known interactions between CBD and Probiotics have been documented in our database. However, always consult a healthcare provider before combining supplements.