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Head-to-head evidence comparison — which supplement is right for you?
Centrophenoxine vs DMAE: their evidence isn't directly comparable (one is unscored); they're alternatives for sharpen focus — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
DMAE wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Old trials used ~1000-2000mg/day in divided doses; no modern validated dose
Morning
Centrophenoxine (meclofenoxate)
Oral: commonly 100-300mg daily (no validated efficacy dose). Topical: 3% gel in the cosmetic trials.
Morning
DMAE bitartrate (oral) or 3% topical gel (skin)
Weeks
Days to weeks
Throughout use
Unknown
Weeks (topical)
Gerontopsychological studies using NAI ('Nurnberger Alters-Inventar') on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial.
Arch Gerontol Geriatr (1989) · Rct · n=50
Double-blind randomized trial in 50 nursing-home residents over 60 with mid-level dementia
The differential effects of meclofenoxate on memory loss in the elderly.
Age Ageing (1977) · Rct
Double-blind study in fit, able elderly subjects
Neuronal lipopigment: a marker for cognitive impairment and long-term effects of psychotropic drugs.
Br J Psychiatry (1989) · Review
Review of neuronal lipopigment (lipofuscin) as a marker of cognitive impairment and aging
The role of dimethylaminoethanol in cosmetic dermatology.
Am J Clin Dermatol (2005) · Review
Review summarizing a placebo-controlled trial of 3% DMAE facial gel over 16 weeks
Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
Skin Res Technol (2002) · Rct · n=30
Two-phase randomized double-blind split-face study (pilot n=8, main n=30) of 3% DMAE gel
Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies.
Psychopharmacology (Berl) (2009) · Preclinical
Combined rat (microdialysis, water-maze, passive-avoidance) and human studies of a DMAE pyroglutamate derivative
DMAE has gradable evidence while Centrophenoxine has insufficient evidence to score and wins in 1 of 3 categories.
For sharpen focus, DMAE has a higher relevance score (24 vs 18).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.