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Head-to-head evidence comparison — which supplement is right for you?
Centrophenoxine vs DMAE: their evidence isn't directly comparable (one is unscored); they're alternatives for sharpen focus — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
DMAE wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Old trials used ~1000-2000mg/day in divided doses; no modern validated dose
morning
Centrophenoxine (meclofenoxate)
Oral: commonly 100-300mg daily (no validated efficacy dose). Topical: 3% gel in the cosmetic trials.
morning
DMAE bitartrate (oral) or 3% topical gel (skin)
Weeks
Days to weeks
Throughout use
Unknown
Weeks (topical)
Gerontopsychological studies using NAI ('Nurnberger Alters-Inventar') on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial.
Arch Gerontol Geriatr (1989) · Rct · n=50
Double-blind randomized trial in 50 nursing-home residents over 60 with mid-level dementia
The differential effects of meclofenoxate on memory loss in the elderly.
Age Ageing (1977) · Rct
Double-blind study in fit, able elderly subjects
Neuronal lipopigment: a marker for cognitive impairment and long-term effects of psychotropic drugs.
Br J Psychiatry (1989) · Review
Review of neuronal lipopigment (lipofuscin) as a marker of cognitive impairment and aging
The role of dimethylaminoethanol in cosmetic dermatology.
Am J Clin Dermatol (2005) · Review
Review summarizing a placebo-controlled trial of 3% DMAE facial gel over 16 weeks
Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
Skin Res Technol (2002) · Rct · n=30
Two-phase randomized double-blind split-face study (pilot n=8, main n=30) of 3% DMAE gel
Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies.
Psychopharmacology (Berl) (2009) · Preclinical
Combined rat (microdialysis, water-maze, passive-avoidance) and human studies of a DMAE pyroglutamate derivative
DMAE has gradable evidence while Centrophenoxine has insufficient evidence to score and wins in 1 of 3 categories.
For sharpen focus, DMAE has a higher relevance score (24 vs 18).
No known interactions between Centrophenoxine and DMAE have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.