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Head-to-head evidence comparison — which supplement is right for you?
Clomiphene (Clomid) vs Enclomiphene: Clomiphene (Clomid) has the stronger overall evidence (4.8 vs 4.2/10); they're alternatives for fertility support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Clomiphene (Clomid) wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Clomiphene (Clomid) and Enclomiphene have evidence — compare verdict strength side-by-side.
Off-label (male) / approved (female) — clinician-directed. For female ovulation induction the approved regimen is 50 mg once daily for 5 days starting early in the cycle, titrated up to 100-150 mg if needed. For off-label male hypogonadism, observational studies used roughly 25-50 mg daily or every other day (25 mg/day is the most common starting dose), titrated to testosterone and LH/FSH response. There is no FDA-approved male dose.
any
Clomiphene citrate tablets (racemic — approved for women; off-label in men)
Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
any
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
Per cycle (5-10 day course)
Weeks to a few months
Within 3-6 months
N/A
Weeks to a few months
Within 3-6 months
N/A
N/A
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Andrology (2022) · Meta analysis · n=1642
Systematic review and meta-analysis of clomiphene citrate for male hypogonadism — 19 studies (4 RCTs, 15 observational), 1,642 patients; 17 studies (1,279 patients) in the meta-analysis
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
N Engl J Med (2014) · Rct · n=750
Double-blind, multicenter RCT (NCT00719186) of 750 women with PCOS randomized 1:1 to letrozole vs clomiphene for up to five cycles; primary outcome live birth
Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome.
Cochrane Database Syst Rev (2016) · Systematic review
Cochrane systematic review of clomiphene and other antioestrogens for ovulation induction in anovulatory PCOS subfertility
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Clomiphene (Clomid) has a higher evidence score (4.8/10 vs 4.2/10) and wins in 2 of 3 categories.
For fertility support, Clomiphene (Clomid) has a higher relevance score (64 vs 60).
No known interactions between Clomiphene (Clomid) and Enclomiphene have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.