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Head-to-head evidence comparison — which supplement is right for you?
Clomiphene (Clomid) vs Omega-3: Omega-3 has the stronger overall evidence (9 vs 4.8/10); they're alternatives for fertility support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Omega-3 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Probably helps
18 of 27 studies with measurable effects showed benefit.
Top outcomes
Off-label (male) / approved (female) — clinician-directed. For female ovulation induction the approved regimen is 50 mg once daily for 5 days starting early in the cycle, titrated up to 100-150 mg if needed. For off-label male hypogonadism, observational studies used roughly 25-50 mg daily or every other day (25 mg/day is the most common starting dose), titrated to testosterone and LH/FSH response. There is no FDA-approved male dose.
any
Clomiphene citrate tablets (racemic — approved for women; off-label in men)
2-3g combined EPA+DHA daily
With meals containing fat
Triglyceride form fish oil
Per cycle (5-10 day course)
Weeks to a few months
Within 3-6 months
N/A
4-8 weeks
2-4 weeks
Immediate
4-12 weeks
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Andrology (2022) · Meta analysis · n=1642
Systematic review and meta-analysis of clomiphene citrate for male hypogonadism — 19 studies (4 RCTs, 15 observational), 1,642 patients; 17 studies (1,279 patients) in the meta-analysis
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
N Engl J Med (2014) · Rct · n=750
Double-blind, multicenter RCT (NCT00719186) of 750 women with PCOS randomized 1:1 to letrozole vs clomiphene for up to five cycles; primary outcome live birth
Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome.
Cochrane Database Syst Rev (2016) · Systematic review
Cochrane systematic review of clomiphene and other antioestrogens for ovulation induction in anovulatory PCOS subfertility
Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
The New England journal of medicine (2019) · Rct · n=25871
During a median follow-up of 5.3 years, a major cardiovascular event occurred in 386 participants in the n-3 group and in 419 in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.80 to 1.06; P=0.24).
Omega-3 fatty acids for intermittent claudication
The Cochrane database of systematic reviews (2024) · Meta analysis · n=1830
Omega-3 compared with a control may have little to no effect on ankle-brachial index (MD -0.02, 95% CI -0.08 to 0.04; 3 studies, 168 participants; very low-certainty evidence).
A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)
Nutritional neuroscience (2024) · Meta analysis · n=587
The present systematic review and meta-analysis indicate the efficacy of omega-3 FAs in increasing the serum concentration of BDNF.
Based on multiple meta-analyses showing EPA-dominant formulas >1g/day most effective. Effects plateau around 2-2.5g. Adjunctive use with antidepressants shows better outcomes than monotherapy.
AI-estimated from published studies. Interpret as directional guidance.
Omega-3 has a higher evidence score (9/10 vs 4.8/10) and wins in 3 of 3 categories.
For fertility support, Omega-3 has a higher relevance score (82 vs 64).
No known interactions between Clomiphene (Clomid) and Omega-3 have been documented in our database. However, always consult a healthcare provider before combining supplements.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.