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Head-to-head evidence comparison — which supplement is right for you?
Devil's Claw vs UC-II: Devil's Claw has the stronger overall evidence (5.5 vs 5/10); they're alternatives for joint health & mobility — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Devil's Claw wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Devil's Claw and UC-II have evidence — compare verdict strength side-by-side.
Standardized extract providing 50-100mg harpagoside daily (≈600-2400mg extract)
With meals
Harpagoside-standardized extract
40mg UC-II daily (providing ~10mg undenatured type II collagen)
Any time of day
Undenatured type II collagen (UC-II, 40mg)
and 1 more not shown
2-8 weeks
2-8 weeks
Days
8-24 weeks
8-16 weeks
Throughout use
Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.
BMC complementary and alternative medicine (2004) · Systematic review
Twelve trials reviewed across OA and low-back pain
Herbal Medicine for Low Back Pain: A Cochrane Review.
Spine (2016) · Systematic review
14 RCTs (2050 participants) of herbal medicines for low-back pain
Herbal medicine for low-back pain.
The Cochrane database of systematic reviews (2014) · Systematic review · n=2050
Devil's claw standardized to 50-100mg harpagoside may beat placebo short-term
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
Nutr J (2016) · Rct · n=191
Multicentre randomised, double-blind trial in 191 people with knee osteoarthritis: UC-II 40 mg/day, glucosamine 1500 mg plus chondroitin 1200 mg, or placebo for 180 days
Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.
Int J Med Sci (2009) · Rct · n=52
90-day trial comparing UC-II with glucosamine plus chondroitin in knee osteoarthritis, with no placebo group
Undenatured type II collagen (UC-II(R)) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.
J Int Soc Sports Nutr (2013) · Rct · n=55
Randomised, double-blind, placebo-controlled 120-day trial in 55 healthy people with knee discomfort only on exertion: UC-II 40 mg/day (n = 27) or placebo (n = 28)
Devil's Claw has a higher evidence score (5.5/10 vs 5/10) and wins in 2 of 3 categories.
Both Devil's Claw and UC-II score equally (65) for joint health & mobility.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.