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Head-to-head evidence comparison — which supplement is right for you?
UC-II wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Devil's Claw and UC-II have evidence — compare verdict strength side-by-side.
Standardized extract providing 50-100mg harpagoside daily (≈600-2400mg extract)
with-meals
Harpagoside-standardized extract
40mg UC-II daily (providing ~10mg undenatured type II collagen)
any
Undenatured type II collagen (UC-II, 40mg)
2-8 weeks
2-8 weeks
Days
8-24 weeks
8-16 weeks
Throughout use
Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.
BMC complementary and alternative medicine (2004) · Systematic review
Twelve trials reviewed across OA and low-back pain
Herbal Medicine for Low Back Pain: A Cochrane Review.
Spine (2016) · Systematic review
14 RCTs (2050 participants) of herbal medicines for low-back pain
Herbal medicine for low-back pain.
The Cochrane database of systematic reviews (2014) · Systematic review
Devil's claw standardized to 50-100mg harpagoside may beat placebo short-term
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
Nutr J (2016) · Rct · n=191
UC-II 40mg/day improved total WOMAC vs placebo over 180 days
Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.
Int J Med Sci (2009) · Rct · n=52
UC-II reduced WOMAC 33% vs 14% for glucosamine+chondroitin
Undenatured type II collagen (UC-II(R)) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.
J Int Soc Sports Nutr (2013) · Rct · n=55
Improved average knee extension range vs placebo
UC-II has a higher evidence score (5/10 vs 5.5/10) and wins in 2 of 3 categories.
Both Devil's Claw and UC-II score equally (65) for joint health & mobility.
No known interactions between Devil's Claw and UC-II have been documented in our database. However, always consult a healthcare provider before combining supplements.