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Head-to-head evidence comparison — which supplement is right for you?
Diosmin vs Horse Chestnut: Diosmin has the stronger overall evidence (7 vs 7/10); they're alternatives for leg circulation & vein health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Diosmin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Diosmin and Horse Chestnut have evidence — compare verdict strength side-by-side.
1000mg MPFF daily (900mg diosmin + 100mg hesperidin); acute hemorrhoid protocols use higher short-term doses (a typical label dose, no cited trial states the dose it used)
With meals
MPFF (micronized diosmin + hesperidin)
300mg standardized extract twice daily (providing ~50mg aescin per dose; ~100mg aescin/day). A typical label dose, no cited trial of oral horse chestnut states its dose.
With meals
Aescin-standardized, enteric-coated seed extract
2-8 weeks
2-8 weeks
Days-weeks
2-12 weeks
2-8 weeks
Days
Efficacy of micronized purified flavonoid fraction (Daflon(R)) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Int Angiol (2018) · Meta analysis
MPFF improved leg symptoms, edema, and quality of life in chronic venous disease
Phlebotonics for venous insufficiency.
Cochrane Database Syst Rev (2020) · Meta analysis · n=7690
Cochrane: phlebotonics probably reduce edema (moderate-certainty evidence)
Phlebotonics for haemorrhoids.
Cochrane Database Syst Rev (2012) · Meta analysis
Phlebotonics improved hemorrhoid symptoms (bleeding, itching, discharge)
Horse chestnut seed extract for chronic venous insufficiency.
The Cochrane database of systematic reviews (2012) · Meta analysis
Significantly reduced leg pain, edema, and itching vs placebo
Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review.
Archives of dermatology (1998) · Systematic review
Most RCTs favored HCSE over placebo
Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
Panminerva medica (2011) · Open label
Improved microcirculatory parameters
Diosmin has a higher evidence score (7/10 vs 7/10) and wins in 2 of 3 categories.
For leg circulation & vein health, Horse Chestnut has a higher relevance score (58 vs 48).
No known interactions between Diosmin and Horse Chestnut have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.