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Head-to-head evidence comparison — which supplement is right for you?
Dutasteride vs Rye Pollen Extract: Dutasteride has the stronger overall evidence (5.4 vs 4.8/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Dutasteride wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Dutasteride and Rye Pollen Extract have evidence — compare verdict strength side-by-side.
Approved BPH dose is 0.5 mg once daily; off-label hair-loss use mirrors the same 0.5 mg once-daily dose under a clinician. A prescription drug.
anytime
Oral soft-gel capsule (dutasteride 0.5 mg)
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
3–6 months
Months
Years
Weeks; may persist
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
Journal of the American Academy of Dermatology (2006) · Rct · n=416
Randomized placebo-controlled trial of 416 men comparing dutasteride doses, finasteride 5 mg, and placebo over 24 weeks
Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study.
Journal of the American Academy of Dermatology (2010) · Rct · n=153
Phase-III randomized double-blind placebo-controlled trial of 153 men over 6 months
The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study.
European urology (2010) · Rct · n=4844
CombAT: 4-year multicenter randomized double-blind trial in 4844 men with symptomatic BPH and prostatic enlargement
Cernilton for benign prostatic hyperplasia
Cochrane Database of Systematic Reviews (2000) · Systematic review · n=444
444 men were enrolled in 2 placebo-controlled and 2 comparative trials lasting from 12 to 24 weeks; three used a double-blind method although treatment allocation concealment was unclear in all.
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
Dutasteride has a higher evidence score (5.4/10 vs 4.8/10) and wins in 2 of 3 categories.
For prostate health, Rye Pollen Extract has a higher relevance score (78 vs 75).
No known interactions between Dutasteride and Rye Pollen Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.