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Head-to-head evidence comparison — which supplement is right for you?
Dutasteride vs Rye Pollen Extract: Dutasteride has the stronger overall evidence (5.4 vs 4.8/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Dutasteride wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (2)
Outcomes where both Dutasteride and Rye Pollen Extract have evidence — compare verdict strength side-by-side.
Approved BPH dose is 0.5 mg once daily; off-label hair-loss use mirrors the same 0.5 mg once-daily dose under a clinician. A prescription drug.
Any time of day
Oral soft-gel capsule (dutasteride 0.5 mg)
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
3–6 months
Months
Years
Weeks; may persist
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
Journal of the American Academy of Dermatology (2006) · Rct · n=416
Randomized placebo-controlled trial of 416 men aged 21-45 comparing dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg and placebo daily for 24 weeks
Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study.
Journal of the American Academy of Dermatology (2010) · Rct · n=153
Phase-III randomized double-blind placebo-controlled trial of 153 men over 6 months
The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study.
European urology (2010) · Rct · n=4844
CombAT: 4-year multicenter randomized double-blind trial in 4,844 men aged 50 or over with symptomatic BPH and prostatic enlargement, comparing tamsulosin 0.4 mg, dutasteride 0.5 mg or both daily, with no placebo arm
Therapeutic efficacy of orally administered pollen for nonallergic diseases: An umbrella review.
Phytotherapy Research (2019) · Systematic review
Reviews support grass pollen extracts for symptomatic BPH and chronic prostatitis
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
Dutasteride has a higher evidence score (5.4/10 vs 4.8/10) and wins in 2 of 3 categories.
For prostate health, Rye Pollen Extract has a higher relevance score (78 vs 75).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.