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Head-to-head evidence comparison — which supplement is right for you?
Dutasteride vs Yohimbe: Dutasteride has the stronger overall evidence (5.4 vs 5/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Dutasteride wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Dutasteride and Yohimbe have evidence — compare verdict strength side-by-side.
Approved BPH dose is 0.5 mg once daily; off-label hair-loss use mirrors the same 0.5 mg once-daily dose under a clinician. A prescription drug.
Any time of day
Oral soft-gel capsule (dutasteride 0.5 mg)
Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content. The one cited trial that states a dose gave a single 10 mg dose.
Morning
Standardized yohimbine HCl (known dose)
and 2 more not shown
3–6 months
Months
Years
Weeks; may persist
2-8 weeks
Acute
Acute
Throughout use
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
Journal of the American Academy of Dermatology (2006) · Rct · n=416
Randomized placebo-controlled trial of 416 men aged 21-45 comparing dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg and placebo daily for 24 weeks
Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study.
Journal of the American Academy of Dermatology (2010) · Rct · n=153
Phase-III randomized double-blind placebo-controlled trial of 153 men over 6 months
The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study.
European urology (2010) · Rct · n=4844
CombAT: 4-year multicenter randomized double-blind trial in 4,844 men aged 50 or over with symptomatic BPH and prostatic enlargement, comparing tamsulosin 0.4 mg, dutasteride 0.5 mg or both daily, with no placebo arm
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
The Journal of urology (1998) · Meta analysis
Yohimbine significantly more effective than placebo for ED
Erectile dysfunction.
BMJ clinical evidence (2011) · Review
Yohimbine has modest ED efficacy
Pharmacological interventions in primary or secondary male anorgasmia: A systematic review.
Actas urologicas espanolas (2025) · Systematic review
Yohimbine among agents assessed for anorgasmia
Dutasteride has a higher evidence score (5.4/10 vs 5/10) and wins in 2 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.