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Head-to-head evidence comparison — which supplement is right for you?
Urolithin A wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
7 of 7 studies with measurable effects showed benefit.
Top outcomes
300-1200mg extract (standardized to 0.8% eleutherosides)
Morning, Before exercise
Standardized root extract
500-1000mg
Morning with food
Mitopure (highly pure, bioavailable form)
2-8 weeks
4-8 weeks
4-8 weeks
8-16 weeks
8-16 weeks
Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials
Nutritional neuroscience (2022) · Systematic review
For most phytonutrients, the effects of supplementation on HPA-axis activity in humans is unclear.
Acanthopanax senticosus: Photochemistry and Anticancer Potential
The American journal of Chinese medicine (2016) · Systematic review
In the past decades, researchers worldwide have conducted systematic investigations on this herb, from chemistry to pharmacology, and a large number of chemical components have been characterized for their significant pharmacological effects.
Acute effectiveness of a "fat-loss" product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise
Journal of the International Society of Sports Nutrition (2015) · Rct · n=12
FAO increased in SHRED from Pre1 to Pre2 [0.56 ± 0.26 to 0.96 ± 0.37, (p = 0.003, d =1.34)] but not in PL [0.67 ± 0.25 to 0.74 ± 0.19, (p = 0.334) d = 0.49], with no differences were found between conditions (p = 0.12, d = 0.49).
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
The American journal of clinical nutrition (2022) · Rct · n=284
Among 284 participants (88% men; mean age: 51 y; BMI: 31.2 kg/m2; APOE-ε4 genotype = 15.7%), 224 (79%) completed the trial with eligible whole-brain MRIs.
Urolithin A induces mitophagy and prolongs lifespan
Nature Medicine (2016) · Preclinical
Extended lifespan in animal models
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Nature aging (2025) · Rct · n=50
Exploratory single-cell RNA sequencing demonstrated UA-driven transcriptional shifts across immune populations, modulating pathways linked to inflammation and metabolism.
Based on limited controlled trials with mixed results. Systematic review noted methodological limitations in existing studies. Effects may be modest and individual response varies significantly.
Based on 3 RCTs (n=88, n=66, n=20) showing improvements in muscle endurance and strength. Effects observed primarily in middle-aged and older adults over 8-16 weeks. Studies used synthetic urolithin A forms with high bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Urolithin A has a higher evidence score (8.5/10 vs 7/10) and wins in 2 of 3 categories.
Both Eleuthero and Urolithin A score equally (75) for boost daily energy.
No known interactions between Eleuthero and Urolithin A have been documented in our database. However, always consult a healthcare provider before combining supplements.