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Head-to-head evidence comparison — which supplement is right for you?
Enclomiphene vs Tongkat Ali: Tongkat Ali has the stronger overall evidence (6 vs 4.2/10); they're alternatives for libido & male vitality — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Tongkat Ali wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Probably helps
2 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Enclomiphene and Tongkat Ali have evidence — compare verdict strength side-by-side.
Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
any
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
200-400mg standardized extract
Morning, With or without food
Standardized root extract (100:1 or 200:1)
Weeks to a few months
Within 3-6 months
N/A
N/A
4-12 weeks
2-4 weeks
2-4 weeks
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack--A Randomized, Double-Blind, Placebo-Controlled, Parallel Study
Phytotherapy research : PTR (2016) · Rct · n=126
The numbers of total, naïve, and CD4(+) T cells were also higher in the TA group than those in P group (p < 0.05).
[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)]
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024) · Systematic review
Tongkat Ali has the main functions of tonifying kidney and replenishing essence, invigorating spleen and replenishing Qi, and soothing liver and relieving depression.
Effect of Eurycoma longifolia standardised aqueous root extract-Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study
Food & Nutrition Research (2021) · Rct · n=105
Significant increase in total testosterone at week 12 (Physta 100 mg) and at weeks 4, 8 and 12 (Physta 200 mg) versus placebo.
Based on meta-analysis showing significant testosterone elevation and multiple RCTs. Effects varied between healthy volunteers and hypogonadal men. Studies primarily used standardized water extracts.
AI-estimated from published studies. Interpret as directional guidance.
Tongkat Ali has a higher evidence score (6/10 vs 4.2/10) and wins in 3 of 3 categories.
For libido & male vitality, Tongkat Ali has a higher relevance score (85 vs 62).
No known interactions between Enclomiphene and Tongkat Ali have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.