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Head-to-head evidence comparison — which supplement is right for you?
Enclomiphene vs Tongkat Ali: Tongkat Ali has the stronger overall evidence (6 vs 4.2/10); they're alternatives for libido & male vitality — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Tongkat Ali wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
1 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Enclomiphene and Tongkat Ali have evidence — compare verdict strength side-by-side.
Investigational / off-label — no FDA-approved dose exists. The cited phase 2 and phase 3 trials gave oral enclomiphene citrate once daily, and neither abstract states the doses used. Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
Any time of day
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
100-200 mg standardized extract (the cited trials used up to 200 mg a day). Label products go up to 400 mg, above that dose.
Morning, With or without food
Standardized root extract (100:1 or 200:1)
Weeks to a few months
Within 3-6 months
N/A
N/A
4-12 weeks
2-4 weeks
2-4 weeks
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack--A Randomized, Double-Blind, Placebo-Controlled, Parallel Study
Phytotherapy research : PTR (2016) · Rct · n=84
Eighty-four of 126 screened middle-aged Japanese subjects took 200 mg/day of TA or rice-powder placebo for 4 weeks. 81 were analysed (40 TA, 41 placebo).
[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)]
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024) · Review
Narrative literature review assigning traditional Chinese medicine properties to Tongkat Ali. It reports no search method and tests no outcome.
Effect of Eurycoma longifolia standardised aqueous root extract-Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study
Food & Nutrition Research (2021) · Rct · n=105
105 men aged 50-70 with testosterone <300 ng/dL took Physta 100 mg, 200 mg or placebo daily for 12 weeks.
The dose points come from one randomised, placebo-controlled trial of 105 men aged 50 to 70 with low testosterone (PMID 34262417), who took 100 mg or 200 mg a day of a standardised water extract (Physta) for 12 weeks. Total testosterone rose more than on placebo at week 12 with 100 mg, and at weeks 4, 8 and 12 with 200 mg. The trial did not report that 200 mg beat 100 mg directly, so no optimal dose is given. It found no clinically relevant safety changes at either dose, which is why the ceiling is 200 mg. An uncontrolled study of 76 men with late-onset hypogonadism also used 200 mg a day for a month and found testosterone rose (PMID 21671978). A meta-analysis of 5 trials found a significant rise in total testosterone (PMID 36013514) but does not compare doses.
AI-estimated from published studies. Interpret as directional guidance.
Tongkat Ali has a higher evidence score (6/10 vs 4.2/10) and wins in 3 of 3 categories.
For libido & male vitality, Tongkat Ali has a higher relevance score (85 vs 62).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.