Enclomiphene vs Yohimbe

Head-to-head evidence comparison — which supplement is right for you?

Quick answerNo interaction data — ask a pharmacist

Enclomiphene vs Yohimbe: Yohimbe has the stronger overall evidence (5 vs 4.2/10); they're alternatives for libido & male vitality — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.

Yohimbe Edges Ahead

Yohimbe wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.

Enclomiphene0 wins

Yohimbe2 wins

Which is right for you? Take the 60-second quiz Open in the full comparison tool

Enc4.2

Enclomiphene

Too few graded studiesLimited safety

Yoh5.0

Yohimbe

Too few graded studiesLimited safety

Evidence

Evidence Score

4.2/10

Studies: 8

Meta-analyses: 1

Level: Emerging

Evidence Score

Best5/10

Studies: 19

Meta-analyses: 1

Level: Moderate

Research findings

Verdict

Too few graded studies

Top outcomes

Testosterone & male hormonesToo few graded studies8
Fertility (sperm preservation)Too few graded studies2

Verdict

Too few graded studies

Top outcomes

Men's vitalityMostly mechanism / observational5
Cognitive functionToo few graded studies2
Endurance & exercise performanceToo few graded studies2

Shared outcomes (1)

Outcomes where both Enclomiphene and Yohimbe have evidence — compare verdict strength side-by-side.

Men's vitalityToo few graded studies8Mostly mechanism / observational5

Dosage & timing

Recommended Dosage:

Investigational — no FDA-approved dose exists. The cited phase 2 and phase 3 trials gave oral enclomiphene citrate once daily, and neither abstract states the doses used. Compounded enclomiphene is used under a clinician at similar doses, but quality and content are not regulated.

Warnings

Enclomiphene is NOT FDA-approved — Androxal failed to gain approval; real-world use is COMPOUNDED, of variable quality and dose.
The genuine, trial-backed claim is narrow: it raises endogenous testosterone (via LH/FSH). A change or preservation of sperm counts in a particular trial does not guarantee fertility or a pregnancy. Any study finding should be read with its preparation, comparator and duration.
Evidence is SHORT-TERM and surrogate-based (testosterone, LH/FSH, sperm count) — there are NO long-term outcome trials for cardiovascular events, bone density, mood, or mortality.
It only works with an intact hypothalamic-pituitary-testicular axis (secondary hypogonadism) — not for primary testicular failure.
Clomiphene-class SERMs carry visual, mood, and (plausibly) thromboembolic concerns; long-term male safety is uncharacterized.
Use only under medical supervision; this is a hormonal compound, not a dietary supplement or a longevity agent.

Best Time:

Any time of day

Can take on empty stomach

Best Form:

Oral enclomiphene citrate (compounded; investigational)

Recommended Dosage:

Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content. The one cited trial that states a dose gave a single 10 mg dose.

Warnings

Raises heart rate and blood pressure — avoid with any cardiovascular risk
Can trigger anxiety and panic attacks
Yohimbe bark supplements have unpredictable yohimbine content that may differ from the label
Dangerous with MAOIs, antidepressants, and other stimulants
Not a casual fat-loss or energy supplement

Best Time:

Morning

Can take on empty stomach

Best Form:

Standardized yohimbine HCl (known dose)

Safety

Limited safetyTie

Drug Interactions:

Exogenous testosterone / anabolic steroids (moderate)
Aromatase inhibitors / other SERMs (e.g. tamoxifen) (moderate)
Estrogens (moderate)

Side Effects:

Visual disturbances (blurring, flashes, floaters)Mood changes / irritabilityHeadache, hot flashes, nausea

Contraindications:

Primary (testicular) hypogonadism — needs an intact pituitary/testis axis to work
Hormone-sensitive tumors or conditions worsened by raising testosterone/estrogen

Limited safetyTie

Drug Interactions:

MAO inhibitors (severe)
SSRIs/SNRIs and other serotonergic/noradrenergic drugs (severe)
Stimulants (caffeine, other sympathomimetics) (severe)

and 2 more not shown

Side Effects:

Increased heart rate and blood pressureAnxiety, restlessness, insomniaHeadache, nausea, sweating

Contraindications:

Hypertension or cardiovascular disease
Anxiety, panic, or other psychiatric disorders

Shared goals

Libido & male vitalityYohimbe

Enclomiphene62/100

Yohimbe68/100

What you'll notice

🧬 Raises endogenous testosteronepositive

Weeks to a few months

👶 Sperm concentration in studied menpositive

Within 3-6 months

⚠️ Investigational / not FDA-approvedtrade-off

N/A

❓ No long-term outcome dataneutral

N/A

💪 Improved erectile functionpositive

2-8 weeks

❤️ Raised heart rate & blood pressuretrade-off

Acute

😰 Anxiety / jitterinesstrade-off

Acute

🎲 Unpredictable potencytrade-off

Throughout use

Key studies

Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.

BJU Int (2016) · Rct

Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism

Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.

Fertil Steril (2014) · Rct

Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)

Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.

J Sex Med (2013) · Open label · n=12

Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone

All Enclomiphene studies

Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.

The Journal of urology (1998) · Meta analysis

Yohimbine significantly more effective than placebo for ED

Erectile dysfunction.

BMJ clinical evidence (2011) · Review

Yohimbine has modest ED efficacy

Pharmacological interventions in primary or secondary male anorgasmia: A systematic review.

Actas urologicas espanolas (2025) · Systematic review

Yohimbine among agents assessed for anorgasmia

All Yohimbe studies

Frequently asked questions

Is Enclomiphene better than Yohimbe?

Yohimbe has a higher evidence score (5/10 vs 4.2/10) and wins in 2 of 3 categories.

Is Enclomiphene or Yohimbe better for libido & male vitality?

For libido & male vitality, Yohimbe has a higher relevance score (68 vs 62).

Can I take Enclomiphene and Yohimbe together?

No documented interaction was found in the data searched. This does not establish that this exact combination is safe.

Related comparisons

Testosterone (TRT) vs Yohimbe Finasteride vs Yohimbe HCG (Human Chorionic Gonadotropin) vs Yohimbe Dutasteride vs Yohimbe

Still deciding between Enclomiphene and Yohimbe?

The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.

Get your personalised pick Enclomiphene details Yohimbe details

Warnings

Enclomiphene is NOT FDA-approved — Androxal failed to gain approval; real-world use is COMPOUNDED, of variable quality and dose.

The genuine, trial-backed claim is narrow: it raises endogenous testosterone (via LH/FSH). A change or preservation of sperm counts in a particular trial does not guarantee fertility or a pregnancy. Any study finding should be read with its preparation, comparator and duration.

Evidence is SHORT-TERM and surrogate-based (testosterone, LH/FSH, sperm count) — there are NO long-term outcome trials for cardiovascular events, bone density, mood, or mortality.

It only works with an intact hypothalamic-pituitary-testicular axis (secondary hypogonadism) — not for primary testicular failure.

Clomiphene-class SERMs carry visual, mood, and (plausibly) thromboembolic concerns; long-term male safety is uncharacterized.

Use only under medical supervision; this is a hormonal compound, not a dietary supplement or a longevity agent.

Warnings

Raises heart rate and blood pressure — avoid with any cardiovascular risk

Can trigger anxiety and panic attacks

Yohimbe bark supplements have unpredictable yohimbine content that may differ from the label

Dangerous with MAOIs, antidepressants, and other stimulants

Not a casual fat-loss or energy supplement

Frequently asked questions

Is Enclomiphene better than Yohimbe?

Yohimbe has a higher evidence score (5/10 vs 4.2/10) and wins in 2 of 3 categories.

Is Enclomiphene or Yohimbe better for libido & male vitality?

For libido & male vitality, Yohimbe has a higher relevance score (68 vs 62).

Can I take Enclomiphene and Yohimbe together?

No documented interaction was found in the data searched. This does not establish that this exact combination is safe.