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Head-to-head evidence comparison — which supplement is right for you?
Enclomiphene vs Yohimbe: Yohimbe has the stronger overall evidence (5 vs 4.2/10); they're alternatives for libido & male vitality — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Yohimbe wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Enclomiphene and Yohimbe have evidence — compare verdict strength side-by-side.
Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
any
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content.
morning
Standardized yohimbine HCl (known dose)
and 2 more not shown
Weeks to a few months
Within 3-6 months
N/A
N/A
2-8 weeks
Acute
Acute
Throughout use
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
The Journal of urology (1998) · Meta analysis
Yohimbine significantly more effective than placebo for ED
Erectile dysfunction.
BMJ clinical evidence (2011) · Review
Yohimbine has modest ED efficacy
Pharmacological interventions in primary or secondary male anorgasmia: A systematic review.
Actas urologicas espanolas (2025) · Systematic review
Yohimbine among agents assessed for anorgasmia
Yohimbe has a higher evidence score (5/10 vs 4.2/10) and wins in 1 of 3 categories.
For libido & male vitality, Yohimbe has a higher relevance score (68 vs 62).
No known interactions between Enclomiphene and Yohimbe have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.