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Head-to-head evidence comparison — which supplement is right for you?
Feverfew vs Iron: Iron has the stronger overall evidence (9 vs 5/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Iron wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
6 of 8 studies with measurable effects showed benefit.
Top outcomes
18.75-56.25 mg daily of a standardized CO2 extract (the cited trial gave 6.24, 18.75 or 56.25 mg a day in three doses, found no effect overall, and only a subgroup on 18.75 mg a day had fewer attacks). Leaf and extract products are labelled at 100-300 mg daily, standardized to at least 0.2-0.7% parthenolide, above the highest dose in the cited trial.
With meals
Standardized CO2 extract (parthenolide-standardized)
18-40mg elemental iron for deficiency (varies by severity) (a typical label dose, not the dose used in the cited trials, which used 60 to 120 mg a day)
On empty stomach if tolerated, Away from tea, coffee, dairy
Ferrous bisglycinate (gentle, well-absorbed) or iron protein succinylate
and 6 more not shown
4-12 weeks
4-8 weeks
Days
On discontinuation
2-4 weeks
4-8 weeks
4-12 weeks
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.
Phytotherapy research : PTR (2016) · Review
Critical appraisal of systematic-review/meta-analysis evidence
Feverfew for migraine prophylaxis: a systematic review.
Journal of dietary supplements (2009) · Systematic review
Some trials showed fewer migraine attacks
Feverfew for preventing migraine.
The Cochrane database of systematic reviews (2015) · Systematic review · n=561
Six trials (561 patients) met inclusion criteria, one new since the 2004 edition
Daily oral iron supplementation during pregnancy
The Cochrane database of systematic reviews (2024) · Meta analysis · n=48971
There is probably little to no difference in maternal death (2 versus 4 events, RR 0.57, 95% CI 0.12 to 2.69; 3 trials, 14,060 women; moderate-certainty evidence).
The Prevalence of Anemia among Pregnant Women in China: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=1376204
The results showed that the prevalence of anemia, ID, and IDA among pregnant women in China were 30.7% (95% CI: 26.6%, 34.7%), 45.6% (95% CI: 37.0%, 54.2%), and 17.3% (95% CI: 13.9%, 20.7%), respectively.
Treatment for women with postpartum iron deficiency anaemia
The Cochrane database of systematic reviews (2024) · Meta analysis · n=4558
Intravenous iron versus oral iron supplementation The evidence is very uncertain about the effect of intravenous iron on mortality (risk ratio (RR) 2.95, 95% confidence interval (CI) 0.12 to 71.96; P = 0.51; I² = not applicable; 3 RCTs; 1 event; 572 women; very low-certainty evidence).
Iron has a higher evidence score (9/10 vs 5/10) and wins in 3 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
Magnesium, riboflavin, CoQ10 — the supplements with real migraine-prevention evidence (and doses).
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.