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Head-to-head evidence comparison — which supplement is right for you?
L-Theanine and Thiamine are closely matched across evidence, studies, and safety.
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
6 of 11 studies with measurable effects showed benefit.
Top outcomes
100-200mg
Morning with coffee for focus, Evening for relaxation, As needed for stress
Suntheanine® capsules or powder
50-100mg daily; 150-600mg benfotiamine for neuropathy
With food, Morning with other B vitamins
Benfotiamine (fat-soluble, higher bioavailability)
30-60 minutes
30-60 minutes
30-60 minutes
Varies
2-4 weeks
4-8 weeks
4-12 weeks
The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis
Sleep medicine reviews (2025) · Meta analysis · n=897
The findings indicate the potential use of L-theanine in the management of sleep disturbances; however, the lack of studies on "pure" L-theanine warrants further investigation.
Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review
Nutrients (2025) · Systematic review
The evidence revealed the potential use of supplements as complementary ADHD treatments under clinical guidance.
Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems
Nutrients (2023) · Rct · n=160
All the tested supplements were found to ameliorate sleep problems significantly (Analysis 1).
Dietary supplements for dysmenorrhoea
The Cochrane database of systematic reviews (2016) · Meta analysis · n=3101
Supplements versus other supplementsThere was no evidence of a difference in effectiveness between ginger and zinc sulphate (MD 0.02 points, 95% CI -0.58 to 0.62; one RCT, 101 women).
Evaluation of the Efficacy of the Addition of a Combination of Pyrimidine Nucleotides and Vitamin B1 and B12 to Standard Treatment in the Management of Painful Radiculopathy and in the Quality of Life of Patients
Nutrients (2024) · Rct · n=122
Both groups showed pain improvement, but the VAS reduction (control: 24.58 vs. experimental: 31.35) was not statistically significant.
Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Nutritional neuroscience (2023) · Systematic review · n=2256
Systematic review examining Thiamine efficacy
Meta-analysis (n=897) and multiple RCTs support sleep benefits. Studies often used L-theanine in combination with other compounds, limiting pure L-theanine effect attribution. Effects include reduced sleep onset latency and improved subjective sleep quality.
Based on limited RCT evidence showing VAS pain reduction with B-vitamin combinations. Effect magnitude conservative due to mixed statistical significance. Higher bioavailability forms like benfotiamine likely more effective than standard thiamine HCl.
AI-estimated from published studies. Interpret as directional guidance.
Both L-Theanine and Thiamine are closely matched — the best choice depends on your specific health goals.
For sharpen focus, L-Theanine has a higher relevance score (80 vs 55).
No known interactions between L-Theanine and Thiamine have been documented in our database. However, always consult a healthcare provider before combining supplements.