Head-to-head evidence comparison — which supplement is right for you?
Myo-Inositol and Thiamine are closely matched across evidence, studies, and safety.
2-4g daily for PCOS; up to 12-18g for anxiety
Divided doses with meals, Morning and evening
Myo-inositol powder
50-100mg daily; 150-600mg benfotiamine for neuropathy
With food, Morning with other B vitamins
Benfotiamine (fat-soluble, higher bioavailability)
3-6 months
4-6 weeks
2-3 months
Initial use or high doses
2-4 weeks
4-8 weeks
4-12 weeks
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes
The Cochrane database of systematic reviews (2023) · Meta analysis · n=1319
For the primary neonatal outcomes, only one study measured the risk of a large-for-gestational-age infant and found myo-inositol was associated with both appreciable benefit and harm (RR 1.40, 95% CI 0.65 to 3.02; 1 study, 234 infants; low-certainty evidence).
Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2022) · Meta analysis · n=1321
Pooled results were expressed as relative risk (RR) or mean difference (MD) with a 95% confidence interval (95% CI).
Short period-administration of myo-inositol and metformin on hormonal and glycolipid profiles in patients with polycystic ovary syndrome: a systematic review and updated meta-analysis of randomized controlled trials
European review for medical and pharmacological sciences (2022) · Meta analysis · n=612
Compared with metformin, the suitable supplemental dosage of myo-ins may be helpful in lowering levels of TG and avoiding adverse events (AEs).
Dietary supplements for dysmenorrhoea
The Cochrane database of systematic reviews (2016) · Meta analysis · n=3101
Supplements versus other supplementsThere was no evidence of a difference in effectiveness between ginger and zinc sulphate (MD 0.02 points, 95% CI -0.58 to 0.62; one RCT, 101 women).
Efficacy and safety of fedratinib in patients with myelofibrosis previously treated with ruxolitinib (FREEDOM2): results from a multicentre, open-label, randomised, controlled, phase 3 trial
The Lancet. Haematology (2024) · Rct · n=316
Clinical trial examining Thiamine efficacy
Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Clinical nutrition (Edinburgh, Scotland) (2024) · Meta analysis · n=3494
Conversely, thiamine administration resulted in a slight increase in the length of ICU stay (MD, 0.40 days; 95% CI, 0.01-0.79 days; High CoE).
Both Myo-Inositol and Thiamine are closely matched — the best choice depends on your specific health goals.
For fertility support, Myo-Inositol has a higher relevance score (92 vs 70).
No known interactions between Myo-Inositol and Thiamine have been documented in our database. However, always consult a healthcare provider before combining supplements.