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Head-to-head evidence comparison — which supplement is right for you?
L. acidophilus vs L. plantarum 299v: L. plantarum 299v has the stronger overall evidence (5 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
L. plantarum 299v wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
1-100 billion CFU (10^9 to 10^11) per serving — the range FDA reviewed without objection for L. acidophilus DDS-1 in foods generally (GRAS Notice GRN 871); La-14 was noticed at 1 billion CFU per 250 g serving (GRN 502)
any
A product naming its strain (e.g. NCFM, DDS-1, La-14, La-5)
1 x 10^9 CFU (1 billion) daily taken WITH the iron-containing meal is sufficient for the iron effect — in the dual-isotope crossover trial 10^9 was significant (28.6% vs 18.5%, p<0.028) while 10^10 was NOT (29.1% vs 20.1%, p=0.080). The freeze-dried capsule and IBS trials used 1 x 10^10 CFU daily, and the pregnancy trial used 1 x 10^10 CFU twice daily (2 x 10^10 CFU/day)
with-meals
Freeze-dried capsule standardized to 299v (DSM 9843)
Weeks
Weeks
Course of antibiotics
Immediate, per meal
12-25 weeks
4 weeks
n/a
Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial.
Nutrients (2020) · Rct
Multicentre randomised controlled trial in irritable bowel syndrome (PubMed publication types: Randomized Controlled Trial, Multicenter Study)
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial.
Nutr J (2016) · Crossover
Randomised, double-blind, placebo-controlled crossover trial (PubMed publication types: Randomized Controlled Trial)
Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial.
Lancet (2013) · Rct
Randomised, double-blind, placebo-controlled multicentre trial in inpatients aged 65 and over (PubMed publication types: Randomized Controlled Trial, Multicenter Study)
A Systematic Review and Meta-Analysis on the Effects of Probiotic Species on Iron Absorption and Iron Status.
Nutrients (2019) · Meta analysis
Pooled SMD 0.55 (95% CI 0.22-0.88, p=0.001) for increased iron absorption across 8 studies
The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial.
Acta Obstet Gynecol Scand (2021) · Rct · n=326
Iron deficiency at week 35: 59% vs 78% (p=0.017); iron-deficiency anaemia 7.4% vs 21% (p=0.023)
Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Gastroenterology (2023) · Meta analysis
For global IBS symptoms, certainty of evidence was LOW for this strain (moderate only for Escherichia strains)
L. plantarum 299v has a higher evidence score (5/10 vs 5/10) and wins in 1 of 3 categories.
For improve digestion, L. acidophilus has a higher relevance score (55 vs 50).
No known interactions between L. acidophilus and L. plantarum 299v have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.