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Head-to-head evidence comparison — which supplement is right for you?
L. rhamnosus GG vs Saccharomyces Boulardii: they're closely matched on evidence (6 vs 8.5/10); they work on different things and are often used together, not either/or. Take the 60-second quiz for a pick tailored to your goals.
L. rhamnosus GG and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
12 of 14 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both L. rhamnosus GG and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
10-20 billion CFU (1-2 x 10^10) daily; 10 billion CFU/day is the effective floor
any
Capsule standardized to ATCC 53103
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
Two independently evidenced routes to the same outcome, with non-overlapping vulnerability to antibiotics.
A defensible pairing during a course of antibiotics. The same immunocompromise and central-line cautions apply to both as live organisms.
During the antibiotic course
During hospital stay
n/a
n/a
During use
1-3 days
1-2 weeks
Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children.
N Engl J Med (2018) · Rct · n=971
Primary outcome (modified Vesikari score >=9 within 14 days): 11.8% with LGG vs 12.6% placebo; RR 0.96 (0.68-1.35), P=0.83
Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults.
Aliment Pharmacol Ther (2015) · Meta analysis
Antibiotic-associated diarrhea fell from 22.4% to 12.3%; RR 0.49 (0.29-0.83) pooled across 11 RCTs, n=1,308 (12 RCTs, n=1,499 included overall)
Probiotics for treating acute infectious diarrhoea.
Cochrane Database Syst Rev (2020) · Meta analysis
In studies at low risk of bias, no difference in diarrhea lasting >=48 hours (RR 1.00, 0.91-1.09; moderate certainty)
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both L. rhamnosus GG and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
For improve digestion, L. rhamnosus GG has a higher relevance score (72 vs 70).
L. rhamnosus GG and Saccharomyces Boulardii may work well together: Two independently evidenced routes to the same outcome, with non-overlapping vulnerability to antibiotics. A defensible pairing during a course of antibiotics. The same immunocompromise and central-line cautions apply to both as live organisms.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.