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Head-to-head evidence comparison — which supplement is right for you?
Lavender and Skullcap are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
80 mg oral Silexan daily OR aromatherapy inhalation 30–60 min sessions
Evening before bed for sleep and anxiety, Acute use before stressful procedures or events
Oral Silexan capsule (80 mg) for systemic/psychiatric use
350-450mg dried herb OR 1-2ml tincture (1:5), up to 3x daily
Before bed for sleep, During day for anxiety as needed
Fresh plant tincture (most traditional)
1–4 weeks
1–3 weeks
4–8 weeks
Acute to 2 weeks
30-60 minutes
30-60 minutes before bed
Effects of lavender on anxiety: A systematic review and meta-analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology (2019) · Meta analysis
Meta-analysis confirmed significant anxiolytic effects of lavender across multiple administration routes
Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2023) · Meta analysis
Silexan 80 mg/day was significantly superior to placebo in reducing Hamilton Anxiety Rating Scale (HAMA) total scores
Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2019) · Meta analysis
Silexan 80 mg/day significantly reduced HAMA scores compared to placebo in subthreshold anxiety
Baicalin and baicalein against myocardial ischemia-reperfusion injury: A review of the current documents
Tissue & cell (2025) · Systematic review
Research in both animal and cell models suggests that these flavonoids, especially baicalin, can restore cardiac health following MIRI, improving cardiac performance, and reducing cardiac damage.
Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases
International journal of molecular sciences (2023) · Systematic review
It has been documented that the extract of Baikal skullcap (Scutellaria baicalensis) has hepatoprotective, calming, antiallergic, and anti-inflammatory properties.
Wogonin and its analogs for the prevention and treatment of cancer: A systematic review
Phytotherapy research : PTR (2022) · Systematic review
WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity.
Based on single crossover RCT (n=43) showing significant group effect for mood in healthy volunteers. Study population was relatively non-anxious (81% mildly anxious or less). Carryover effects noted. Limited evidence base requires further validation in clinical populations.
AI-estimated from published studies. Interpret as directional guidance.
Both Lavender and Skullcap are closely matched — the best choice depends on your specific health goals.
For reduce anxiety & stress, Lavender has a higher relevance score (90 vs 75).
No known interactions between Lavender and Skullcap have been documented in our database. However, always consult a healthcare provider before combining supplements.