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Head-to-head evidence comparison — which supplement is right for you?
Liraglutide vs White Willow Bark: White Willow Bark has the stronger overall evidence (6 vs 7.5/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
White Willow Bark wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
Prescription-only, clinician-titrated, subcutaneous once daily. Diabetes (Victoza): escalate 0.6 → 1.2 → 1.8 mg/day. Weight management (Saxenda): escalate weekly to 3.0 mg/day. DO NOT self-dose.
any
Subcutaneous once-daily injection (Victoza for diabetes, Saxenda for weight)
120-240mg salicin daily (from standardized extract)
With meals, Divided doses
Standardized extract (15% salicin)
Weeks to months
Months (titrated over weeks)
Months to years
Especially during dose escalation
1-2 weeks
1-4 weeks
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes (LEADER).
N Engl J Med (2016) · Rct · n=9340
Double-blind cardiovascular-outcomes RCT: 9,340 patients with type 2 diabetes and high cardiovascular risk, liraglutide (up to 1.8 mg/day) vs placebo, median follow-up 3.8 years
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management (SCALE Obesity and Prediabetes).
N Engl J Med (2015) · Rct · n=3731
56-week double-blind RCT in 3,731 adults WITHOUT type 2 diabetes (BMI ≥30, or ≥27 with comorbidities), liraglutide 3.0 mg/day vs placebo plus lifestyle (2:1)
Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.
JAMA (2015) · Rct · n=846
56-week double-blind RCT in 846 adults with overweight/obesity AND type 2 diabetes, liraglutide 3.0 mg vs 1.8 mg vs placebo (2:1:1)
Efficacy and Safety of White Willow Bark (Salix alba) Extracts
Phytotherapy research : PTR (2015) · Systematic review
In recent years, various in vitro and animal studies have demonstrated that the anti-inflammatory activity of willow bark extract is associated with down regulation of the inflammatory mediators tumor necrosis factor-α and nuclear factor-kappa B.
A systematic review on the effectiveness of willow bark for musculoskeletal pain
Phytotherapy research : PTR (2009) · Systematic review
All studies investigated ethanolic extracts with daily doses up to 240 mg salicin over periods of up to six weeks.
Cochrane review: Herbal therapy for low back pain
Cochrane Database of Systematic Reviews (2006) · Systematic review · n=500
Moderate evidence of efficacy
Based on Cochrane review showing dose-response relationship with 240mg more effective than 120mg. Studies limited to 6 weeks duration. Requires salicin-standardized extract.
AI-estimated from published studies. Interpret as directional guidance.
White Willow Bark has a higher evidence score (6/10 vs 7.5/10) and wins in 2 of 3 categories.
No known interactions between Liraglutide and White Willow Bark have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.