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Head-to-head evidence comparison — which supplement is right for you?
Losartan vs Rosuvastatin (Crestor): Rosuvastatin (Crestor) has the stronger overall evidence (4.5 vs 4.2/10); they're alternatives for support heart health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Rosuvastatin (Crestor) wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Losartan and Rosuvastatin (Crestor) have evidence — compare verdict strength side-by-side.
Off-label longevity/muscle-aging use mirrors low antihypertensive dosing (25–100 mg once daily) under a clinician. Not an approved longevity or anti-sarcopenia regimen; blood pressure, kidney function, and potassium should be monitored.
any
Oral tablet (losartan potassium)
5–20 mg once daily (up to 40 mg in selected high-risk patients), titrated to LDL/ApoB targets — under a clinician. A prescription drug; not a self-directed supplement regimen.
any
Oral tablet (rosuvastatin 5–20 mg)
Months to years
Years
Unknown in humans
Throughout use
2–4 weeks
Months to years
1–2 years
Throughout use
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Lancet (London, England) (2002) · Rct · n=9193
LIFE randomized trial in hypertensives with left-ventricular hypertrophy
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.
The New England journal of medicine (2001) · Rct · n=1513
RENAAL randomized, double-blind trial in type-2 diabetic nephropathy
Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia.
Science translational medicine (2011) · Animal
In sarcopenic mice, losartan reduced fibrosis and improved muscle function after injury
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
The New England journal of medicine (2008) · Rct · n=17802
JUPITER randomized placebo-controlled primary-prevention trial (~17,800 participants with normal LDL but elevated hsCRP)
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.
Lancet (London, England) (2010) · Meta analysis
Meta-analysis of ~170,000 participants across 26 randomized statin trials
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.
JAMA (2006) · Open label · n=507
ASTEROID open-label IVUS trial (507 enrolled; 349 with evaluable serial imaging)
Rosuvastatin (Crestor) has a higher evidence score (4.5/10 vs 4.2/10) and wins in 2 of 3 categories.
For support heart health, Rosuvastatin (Crestor) has a higher relevance score (78 vs 66).
No known interactions between Losartan and Rosuvastatin (Crestor) have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.