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Head-to-head evidence comparison — which supplement is right for you?
Lutein + Zeaxanthin and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
10mg lutein + 2mg zeaxanthin
With a meal containing fat
Softgels with both lutein and zeaxanthin
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
3-6 months
4-8 weeks
3-6 months
During use
1-3 days
1-2 weeks
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis
The American journal of clinical nutrition (2016) · Meta analysis · n=387569
Meta-analysis showed a lower risk of coronary heart disease (pooled RR: 0.88; 95% CI: 0.80, 0.98) and stroke (pooled RR: 0.82; 95% CI: 0.72, 0.93) for the highest compared with the lowest tertile of lutein blood concentration or intake.
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration
The Cochrane database of systematic reviews (2023) · Systematic review · n=2445
These studies enroled 11,952 people aged 65 to 75 years and included slightly more women (on average 56% women).
Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28
JAMA ophthalmology (2022) · Rct · n=3882
This study included 3882 participants (mean [SD] baseline age, 72.0 [7.7] years; 2240 women [57.7%]) and 6351 eyes.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on multiple meta-analyses showing significant MPOD increases in both AMD patients and healthy subjects. Effect size modest but consistent across studies. Higher doses may increase carotenodermia risk.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Lutein + Zeaxanthin and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
No known interactions between Lutein + Zeaxanthin and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.