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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Peppermint Oil and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
180-225mg enteric-coated peppermint oil, 2-3 times daily before meals
before-meals
Enteric-coated capsules
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
Within hours to 4 weeks
Days to weeks
Soon after dosing
During use
1-3 days
1-2 weeks
The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.
BMC Complement Altern Med (2019) · Meta analysis · n=835
12 randomized trials, 835 patients pooled
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
J Clin Gastroenterol (2014) · Meta analysis · n=726
9 randomized placebo-controlled trials, 726 patients
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Complement Ther Med (2020) · Meta analysis
33 double-blind placebo-controlled trials reviewed; 17 evaluated peppermint oil
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Saccharomyces Boulardii has a higher evidence score (8.5/10 vs 7/10) and wins in 2 of 3 categories.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 30).
No known interactions between Peppermint Oil and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.