Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii and Shiitake are closely matched across evidence, studies, and safety.
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Saccharomyces Boulardii and Shiitake have evidence — compare verdict strength side-by-side.
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
5-15g dried mushroom or 1-3g extract daily
With meals, Divided doses if using higher amounts
Shiitake extract (standardized to polysaccharides)
During use
1-3 days
1-2 weeks
4 weeks
8-12 weeks
4-8 weeks
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years
Nutrients (2025) · Systematic review
In recent years, the incidence rate of cancer has been on the rise all over the world, and the age of cancer patients has shown a younger trend, which seriously endangers patients' health.
Vitamin B12 sources in non-animal foods: a systematic review
Critical reviews in food science and nutrition (2023) · Systematic review · n=25
In the last decade, more sensitive method for real B12 determination was used, the liquid chromatography-electrospray ionization tandem mass spectrometry chromatograms.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Systematic review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
Based on beta-glucan studies and one pilot RCT (n=239) showing modest immune response trends. Evidence limited by small sample sizes and primarily preclinical data. Effects may vary significantly by extract standardization and processing method.
AI-estimated from published studies. Interpret as directional guidance.
Both Saccharomyces Boulardii and Shiitake are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 60).
No known interactions between Saccharomyces Boulardii and Shiitake have been documented in our database. However, always consult a healthcare provider before combining supplements.