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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
Prescription topical: a pea-sized amount of 0.025%-0.1% cream or gel applied to clean, dry skin once nightly. Start low-strength and every-other-night to build tolerance. A prescription drug used under clinician direction — not a supplement regimen.
before-bed
Topical cream or gel, 0.025%-0.1% (prescription)
During use
1-3 days
1-2 weeks
12-24 weeks
12-24 weeks
Months
8-12 weeks
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study.
JAMA (1988) · Rct
Randomized, double-blind, vehicle-controlled trial of topical tretinoin for photoaged forearm and facial skin
Tretinoin emollient cream: a new therapy for photodamaged skin.
J Am Acad Dermatol (1992) · Rct
Multicenter double-blind vehicle-controlled trial of tretinoin emollient cream for photodamaged skin
Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis.
J Am Acad Dermatol (2005) · Open label
Long-term topical retinoic acid on photoaged human skin assessed histologically
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Saccharomyces Boulardii has a higher evidence score (8.5/10 vs 8/10) and wins in 3 of 3 categories.
No known interactions between Saccharomyces Boulardii and Tretinoin (Retin-A) have been documented in our database. However, always consult a healthcare provider before combining supplements.