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Head-to-head evidence comparison — which supplement is right for you?
Sildenafil (Viagra) wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Sildenafil (Viagra) and Vardenafil (Levitra) have evidence — compare verdict strength side-by-side.
Approved on-demand ED dosing is 25-100 mg taken ~30-60 minutes before activity (50 mg typical start). PAH dosing (Revatio) is 20 mg three times daily. Any off-label use is clinician-directed; this is not an approved longevity regimen.
any
Oral tablet (sildenafil citrate)
Approved on-demand ED dosing is 5-20 mg taken ~30-60 minutes before activity (10 mg typical start for the film-coated tablet); the orodispersible Staxyn tablet is 10 mg. Any use is clinician-directed and prescription-only; this is not a supplement regimen.
any
Oral film-coated tablet (vardenafil HCl)
Acute (~30-60 min onset)
Weeks
Years
Years
Acute (~30-60 min onset)
Weeks
Acute (per dose)
With interacting drugs / at-risk patients
Oral sildenafil in the treatment of erectile dysfunction.
The New England Journal of Medicine (1998) · Rct
Two sequential double-blind randomized trials of on-demand oral sildenafil in men with erectile dysfunction
Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixed-dose regimen randomized controlled trials administering the International Index of Erectile Function in broad-spectrum populations.
International Journal of Impotence Research (2006) · Meta analysis
Comparative meta-analysis pooling fixed-dose RCTs of sildenafil, tadalafil, and vardenafil
Sildenafil citrate therapy for pulmonary arterial hypertension.
The New England Journal of Medicine (2005) · Rct
SUPER-1: randomized, double-blind, placebo-controlled trial in 278 patients with PAH
The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial.
International Journal of Impotence Research (2001) · Rct
Multicentre, randomized, double-blind, placebo-controlled at-home trial in 601 men with mild-to-severe erectile dysfunction
Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study.
Diabetes Care (2003) · Rct
Prospective multicenter double-blind placebo-controlled fixed-dose RCT in men with diabetes and erectile dysfunction
Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy.
The Journal of Urology (2003) · Rct
Randomized, double-blind, placebo-controlled trial in men with erectile dysfunction after radical retropubic prostatectomy
Sildenafil (Viagra) has a higher evidence score (3.8/10 vs 3.6/10) and wins in 1 of 3 categories.
No known interactions between Sildenafil (Viagra) and Vardenafil (Levitra) have been documented in our database. However, always consult a healthcare provider before combining supplements.